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Alain Fautrel
Researcher at University of Rennes
Publications - 72
Citations - 2906
Alain Fautrel is an academic researcher from University of Rennes. The author has contributed to research in topics: In vivo & Gene expression. The author has an hindex of 28, co-authored 69 publications receiving 2698 citations. Previous affiliations of Alain Fautrel include French Institute of Health and Medical Research & European University of Brittany.
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Journal Article
Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.
Ziad Abdel-Razzak,Pascal Loyer,Alain Fautrel,J.-C. Gautier,Laurent Corcos,B. Turlin,Philippe Beaune,André Guillouzo +7 more
TL;DR: These results provide the first demonstration that various cytokines act directly on human hepatocytes to affect expression of major P-450 genes and that a wide range of responses can be observed among the enzymes for a given cytokine, suggesting that different regulatory mechanisms may be involved.
Journal ArticleDOI
IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis.
Paméla Gasse,Nicolas Riteau,Rachel Vacher,Marie-Laure Michel,Alain Fautrel,Franco Di Padova,Lizette Fick,Sabine Charron,Vincent Lagente,Gérard Eberl,Marc Le Bert,Valérie F. J. Quesniaux,François Huaux,Maria Leite-de-Moraes,Bernhard Ryffel,Bernhard Ryffel,Isabelle Couillin +16 more
TL;DR: The findings demonstrate the existence of an early IL-1β-IL-23- IL- 17A axis leading to pulmonary inflammation and fibrosis and identify innate IL-23 and IL-17A as interesting drug targets for IL- 1β driven lung pathology.
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Viability and function in primary culture of adult hepatocytes from various animal species and human beings after cryopreservation
Christophe Chesne,Claire Guyomard,Alain Fautrel,Marie-gwenaëlle Poullain,Benjamin Fremond,Hendrik de Jong,André Guillouz +6 more
TL;DR: The results show that a simple and reproducible freeze/thaw protocol can be used to cryopreserve hepatocytes from various species including human beings and that after thawing a large fraction of the cells is still viable and capable of expressing various functions in vitro.
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Ectopic Germinal Centers Are Rare in Sjögren’s Syndrome Salivary Glands and Do Not Exclude Autoreactive B Cells
Laëtitia Le Pottier,Valérie Devauchelle,Alain Fautrel,Capucine Daridon,Alain Saraux,Pierre Youinou,Jacques-Olivier Pers +6 more
TL;DR: Characterization of B cells of germinal center (GC)-like structures infiltrating the salivary glands of patients with Sjögren’s syndrome indicates that, in SGs, a minority of B cell clusters represent genuine GC cells, while the majority manifest features of being type 2 transitional B cells and marginal zone cells.
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Molecular profiling of stroma identifies osteopontin as an independent predictor of poor prognosis in intrahepatic cholangiocarcinoma.
Laurent Sulpice,Michel Rayar,Mireille Desille,Mireille Desille,Bruno Turlin,Bruno Turlin,Alain Fautrel,Alain Fautrel,Eveline Boucher,Eveline Boucher,Francisco Llamas-Gutierrez,Bernard Meunier,Karim Boudjema,Karim Boudjema,Bruno Clément,Bruno Clément,Cédric Coulouarn,Cédric Coulouarn +17 more
TL;DR: The study identifies clinically relevant genomic alterations in the stroma of ICC, including candidate biomarkers for prognosis, supporting the idea that tumor stroma is an important factor for ICC onset and progression.