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Alain Lachaux
Researcher at Claude Bernard University Lyon 1
Publications - 252
Citations - 5014
Alain Lachaux is an academic researcher from Claude Bernard University Lyon 1. The author has contributed to research in topics: Liver transplantation & Liver disease. The author has an hindex of 31, co-authored 233 publications receiving 4133 citations. Previous affiliations of Alain Lachaux include Boston Children's Hospital & University of Lyon.
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Journal ArticleDOI
Impact of Age at Kasai Operation on Its Results in Late Childhood and Adolescence: A Rational Basis for Biliary Atresia Screening
Marie-Odile Serinet,Barbara E. Wildhaber,Pierre Broué,Alain Lachaux,Jacques Sarles,Emmanuel Jacquemin,Frédéric Gauthier,Christophe Chardot +7 more
TL;DR: Findings indicate a rational basis for biliary atresia screening to reduce the need for liver transplantations in infancy and childhood and suggest increased age at surgery had a progressive and sustained deleterious effect on the results of the Kasai operation until adolescence.
Journal ArticleDOI
Interferon alfa therapy for chronic hepatitis B in children: a multinational randomized controlled trial
Etienne Sokal,Hari S. Conjeevaram,Eve A. Roberts,Fernando Alvarez,Elana M. Bern,Philippe Goyens,Philip J. Rosenthal,Alain Lachaux,M Shelton,Jacques Sarles,Jay H. Hoofnagle +10 more
TL;DR: In children with chronic hepatitis B, INF-alpha promotes loss of viral replication markers and surface antigen and improves aminotransferases and histology and reduces dose in 24% of children.
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Improving outcomes of biliary atresia: French national series 1986-2009.
Christophe Chardot,Chantal Buet,Marie-Odile Serinet,Jean-Louis Golmard,Alain Lachaux,Bertrand Roquelaure,Frédéric Gottrand,Pierre Broué,Alain Dabadie,Frédéric Gauthier,Emmanuel Jacquemin +10 more
TL;DR: Early Kasai operation, without age threshold, reduces the need for liver transplantation until adulthood, and BA patients currently have an 89% live expectancy, and a 30% chance to reach adulthood without transplantation.
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Liver transplantation for glycogen storage disease types I, III, and IV
Dietrich Matern,Thomas E. Starzl,W Arnaout,J Barnard,JS Bynon,Anil Dhawan,J Emond,EB Haagsma,G. Hug,Alain Lachaux,Gerrit Smit,Yuan-Tsong Chen +11 more
TL;DR: Liver transplantation should be considered for patients with glycogen storage disease who have developed liver malignancy or hepatic failure, and for type IV patients with the classical and progressive hepatic form, because of the variable phenotype.
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Management of patients with biliary atresia in France: results of a decentralized policy 1986-2002.
Marie-Odile Serinet,Pierre Broué,Emmanuel Jacquemin,Alain Lachaux,Jacques Sarles,Frédéric Gottrand,Frédéric Gauthier,Christophe Chardot +7 more
TL;DR: BA patients currently have the same chance of survival in France as in England and Wales, but the early success rate of the Kasai operation remains inferior in the centers with limited caseloads in France, leading to a greater need for LTs in infancy and early childhood.