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Alain Sarasin
Researcher at Institut Gustave Roussy
Publications - 330
Citations - 16913
Alain Sarasin is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Xeroderma pigmentosum & DNA repair. The author has an hindex of 70, co-authored 324 publications receiving 16199 citations. Previous affiliations of Alain Sarasin include École Normale Supérieure & Université Paris-Saclay.
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Journal ArticleDOI
Gene Expression Profiling of Primary Cutaneous Melanoma and Clinical Outcome
V. Winnepenninckx,Vladimir Lazar,Stefan Michiels,Philippe Dessen,Marguerite Stas,Soledad R. Alonso,Marie-Françoise Avril,Pablo Luis Ortiz Romero,Thomas Robert,Ovidiu Balacescu,Alexander M.M. Eggermont,Gilbert M. Lenoir,Alain Sarasin,Thomas Tursz,Joost van den Oord,Alain Spatz +15 more
TL;DR: In this article, the authors investigated the relationship between gene expression profiles and clinical outcome in a cohort of patients with primary melanoma and identified 254 genes whose expression was associated with metastatic dissemination of cutaneous melanomas.
Journal Article
Transcription-coupled Nucleotide Excision Repair as a Determinant of Cisplatin Sensitivity of Human Cells
TL;DR: It is reported that TC-NER-deficient cells are hypersensitive to cisplatin irrespective of their GG-NER status, and that gene complementation with XPA and XPD increases resistance to cisPlatin.
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High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation
A Bounacer,R Wicker,Bernard Caillou,A F Cailleux,A F Cailleux,Alain Sarasin,M. Schlumberger,H G Suárez +7 more
TL;DR: The results confirm the crucial role played by the ret proto-oncogene activating rearrangements in the development of radiation-associated thyroid tumors appearing after therapeutic or accidental ionizing irradiation, and show, for the first time, the presence of RET/PTC genes in follicular adenomas appeared after external irradiation.
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Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome.
Florence Le Page,Ely Kwoh,Anna V. Avrutskaya,Alain Gentil,Steven A. Leadon,Alain Sarasin,Priscilla K. Cooper +6 more
TL;DR: Analysis of transcription-coupled repair of oxidative lesions here reveals strand-specific removal of 8-oxo-guanine and thymine glycol both in normal human cells and xeroderma pigmentosum cells defective in nucleotide excision repair.
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Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients
TL;DR: Results show the existence of preferential repair of UV lesions [either pyrimidine dimers or pyridine-pyrimidone (6-4) photoproducts] on the transcribed strand in human tissues.