M
Marie-Françoise Avril
Researcher at Paris Descartes University
Publications - 244
Citations - 13502
Marie-Françoise Avril is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Melanoma & Germline mutation. The author has an hindex of 58, co-authored 244 publications receiving 12498 citations. Previous affiliations of Marie-Françoise Avril include French Institute of Health and Medical Research & University of Paris.
Papers
More filters
Journal ArticleDOI
Gene Expression Profiling of Primary Cutaneous Melanoma and Clinical Outcome
V. Winnepenninckx,Vladimir Lazar,Stefan Michiels,Philippe Dessen,Marguerite Stas,Soledad R. Alonso,Marie-Françoise Avril,Pablo Luis Ortiz Romero,Thomas Robert,Ovidiu Balacescu,Alexander M.M. Eggermont,Gilbert M. Lenoir,Alain Sarasin,Thomas Tursz,Joost van den Oord,Alain Spatz +15 more
TL;DR: In this article, the authors investigated the relationship between gene expression profiles and clinical outcome in a cohort of patients with primary melanoma and identified 254 genes whose expression was associated with metastatic dissemination of cutaneous melanomas.
Journal ArticleDOI
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma
Corine Bertolotto,Fabienne Lesueur,Sandy Giuliano,Thomas Strub,Mahaut de Lichy,Karine Bille,Philippe Dessen,Benoit d’Hayer,Hamida Mohamdi,Audrey Remenieras,Eve Maubec,Arnaud de la Fouchardière,Vincent Molinié,Pierre Vabres,Stéphane Dalle,N. Poulalhon,Tanguy Martin-Denavit,Luc Thomas,Pascale Andry-Benzaquen,Nicolas Dupin,F. Boitier,Annick Rossi,Jean-Luc Perrot,Bruno Labeille,Caroline Robert,Bernard Escudier,Olivier Caron,Laurence Brugières,Simon Saule,Betty Gardie,Sophie Gad,Stéphane Richard,Jérôme Couturier,Bin Tean Teh,Paola Ghiorzo,Lorenza Pastorino,Susana Puig,Celia Badenas,Håkan Olsson,Christian Ingvar,Etienne Rouleau,Rosette Lidereau,Philippe Bahadoran,Philippe Vielh,Eve Corda,Hélène Blanché,Diana Zelenika,Pilar Galan,François Aubin,Bertrand Bachollet,Celine Becuwe,Pascaline Berthet,Yves-Jean Bignon,Valérie Bonadona,Jean -Louis Bonafe,Marie -Noelle Bonnet-Dupeyron,Frédéric Cambazard,Jacqueline Chevrant-Breton,Isabelle Coupier,Sophie Dalac,Liliane Demange,Michel D'Incan,Catherine Dugast,Laurence Faivre,Lynda Vincent-Fetita,Marion Gauthier-Villars,Brigitte Gilbert,Florent Grange,Jean-Jacques Grob,Philippe Humbert,Nicolas Janin,Pascal Joly,Delphine Kerob,Christine Lasset,Dominique Leroux,Julien Levang,Jean -Marc Limacher,Cristina Bulai Livideanu,Michel Longy,Alain Lortholary,Dominique Stoppa-Lyonnet,Sandrine Mansard,Ludovic Mansuy,Karine Marrou,Christine Mateus,Christine Maugard,Nicolas Meyer,Catherine Noguès,Pierre Souteyrand,Laurence Venat-Bouvet,Hélène Zattara,Valérie Chaudru,Gilbert M. Lenoir,Mark Lathrop,Irwin Davidson,Marie-Françoise Avril,Florence Demenais,Robert Ballotti,Brigitte Bressac-de Paillerets +98 more
TL;DR: A germline missense substitution in MITF (Mi-E318K) is identified that occurred at a significantly higher frequency in genetically enriched patients affected with melanoma, RCC or both cancers, when compared with controls and provides insights into the link between SUMOylation, transcription and cancer.
Journal ArticleDOI
Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III study.
Marie-Françoise Avril,Steinar Aamdal,Jean-Jacques Grob,Axel Hauschild,Peter Mohr,Jean Jacques Bonerandi,Michael Weichenthal,K. Neuber,T. Bieber,K. Gilde,V. Guillem Porta,J. Fra,J. Bonneterre,Philippe Saiag,D. Kamanabrou,Hubert Pehamberger,J. Sufliarsky,J. L.Gonzalez Larriba,A. Scherrer,Y. Menu +19 more
TL;DR: ORR was higher in the fotemustine arm compared to the DTIC arm in first-line treatment of disseminated melanoma, and a trend in favor of fotamustine in terms of overall survival and time to BM was evidenced.
Journal ArticleDOI
Genome-wide association study identifies three loci associated with melanoma risk.
D. Timothy Bishop,Florence Demenais,Mark M. Iles,Mark Harland,John C. Taylor,Eve Corda,Eve Corda,Juliette Randerson-Moor,Joanne F. Aitken,Marie-Françoise Avril,Esther Azizi,Bert Bakker,Giovanna Bianchi-Scarrà,Brigitte Bressac-de Paillerets,Donato Calista,Lisa A. Cannon-Albright,Thomas Chin-A-Woeng,Tadeusz Dębniak,Gilli Galore-Haskel,Paola Ghiorzo,Ivo Gut,Johan Hansson,Marko Hočevar,Veronica Höiom,John L. Hopper,Christian Ingvar,Peter A. Kanetsky,Richard F. Kefford,Maria Teresa Landi,Julie Lang,Jan Lubinski,Rona M. MacKie,Josep Malvehy,Graham J. Mann,Nicholas G. Martin,Grant W. Montgomery,Frans A. van Nieuwpoort,Srdjan Novaković,Håkan Olsson,Susana Puig,Marjan M. Weiss,Wilbert van Workum,Diana Zelenika,Kevin M. Brown,Alisa M. Goldstein,Elizabeth M. Gillanders,Anne Boland,Pilar Galan,David E. Elder,Nelleke A. Gruis,Nicholas K. Hayward,G. Mark Lathrop,G. Mark Lathrop,Jennifer H. Barrett,Julia A. Newton Bishop +54 more
TL;DR: Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk.
Journal ArticleDOI
HLA-G expression in melanoma: A way for tumor cells to escape from immunosurveillance
Pascale Paul,Nathalie Rouas-Freiss,Iman Khalil-Daher,Philippe Moreau,Béatrice Riteau,F A Le Gal,Marie-Françoise Avril,Jean Dausset,Jean-Gérard Guillet,Edgardo D. Carosella +9 more
TL;DR: It appears of critical importance to consider the specific role of HLA-G expression in tumors in the design of future cancer immunotherapies.