Alan C. Rapraeger

TL;DR: Prevention of binding between cell surface heparan sulfate and bFGF substantially reduces binding of fibroblast growth factor to its cell-surface receptors, blocks the ability of bF GF to support the growth of Swiss 3T3 fibroblasts, and induces terminal differentiation of MM14 skeletal muscle cells, which is normally repressed by fibro Blast growth factor.

TL;DR: It is concluded that specific saccharide sequences within heparan sulfate glycosaminoglycan chains favor the signaling by distinct members of the FGF family.

TL;DR: Examination of the expression of syndecans 1-4 in embryonic, fetal, postnatal, and adult muscle tissue, as well as on primary adult muscle fiber cultures, suggests that syndecan-3 and syndECan-4 may play important regulatory roles in satellite cell maintenance, activation, proliferation, and differentiation during skeletal muscle regeneration.

TL;DR: It is suggested that the proteoglycan, initially present on the entire surface and free in the plane of the membrane, becomes sequestered at the basolateral cell surface and bound to the actin-rich cytoskeleton as the cells become polarized in vitro.

TL;DR: While there are fewer apparent defects in syndecan-4(-/-) muscle, explanted satellite cells are deficient in activation, proliferation, MyoD expression, myotube fusion, and differentiation, suggesting a unique requirement for syndecans-4 in satellite cell function.