B
Bradley B. Olwin
Researcher at University of Colorado Boulder
Publications - 98
Citations - 11101
Bradley B. Olwin is an academic researcher from University of Colorado Boulder. The author has contributed to research in topics: Skeletal muscle & Myocyte. The author has an hindex of 47, co-authored 95 publications receiving 10447 citations. Previous affiliations of Bradley B. Olwin include University of Colorado Denver & University of Washington.
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Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation.
TL;DR: Prevention of binding between cell surface heparan sulfate and bFGF substantially reduces binding of fibroblast growth factor to its cell-surface receptors, blocks the ability of bF GF to support the growth of Swiss 3T3 fibroblasts, and induces terminal differentiation of MM14 skeletal muscle cells, which is normally repressed by fibro Blast growth factor.
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Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.
TL;DR: It is concluded that specific saccharide sequences within heparan sulfate glycosaminoglycan chains favor the signaling by distinct members of the FGF family.
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Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self-renewal.
Hugo C. Olguín,Bradley B. Olwin +1 more
TL;DR: Analysis of Pax-7 expression in activated satellite cells unexpectedly revealed substantial heterogeneity within individual clones, and data support the concept that satellite cell self-renewal may be a primary mechanism for replenishment of the satellite cell compartment during skeletal muscle regeneration.
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FGF-2: apical ectodermal ridge growth signal for chick limb development
TL;DR: Ectopic fibroblast growth factor (FGF)-2 supplied to the chick apical bud mesoderm after ridge removal will sustain normal gene expression and cell viability, and allow relatively normal limb development.
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Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor.
TL;DR: Comparison of MM14 behavior with other myoblast types suggests a general model for skeletal muscle development in which specific growth factors serve the dual role of stimulating myOBlast proliferation and directly repressing terminal differentiation.