A
Alan D. Friedman
Researcher at Johns Hopkins University
Publications - 95
Citations - 5567
Alan D. Friedman is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Ccaat-enhancer-binding proteins & Myeloid. The author has an hindex of 42, co-authored 93 publications receiving 5356 citations. Previous affiliations of Alan D. Friedman include Hochschule Hannover & National Institutes of Health.
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Journal ArticleDOI
Transcriptional control of granulocyte and monocyte development.
TL;DR: PU.1 directs the hematopoietic stem cell to the lymphoid-myeloid progenitor (LMP) and interacts with GATA-binding protein 1 to inhibit commitment to the megakaryocyte-erythroid progenitors (GMP) stage, while inhibiting lymphoid development via cross-inhibition of Pax5 and potentially other regulators.
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A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells.
TL;DR: These studies show a unique temporal pattern of C/EBP isoform expression in the myeloid lineage, which is very high in proliferative myelomonocytic cells, and diminishes during phenotypic maturation.
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Transcriptional regulation of granulocyte and monocyte development
TL;DR: Granulocytes and monocytes develop from a common myeloid progenitor and can be induced by Maf-B, c-Jun, or Egr-1 and is dependent upon PU.1, Sp1, and ICSBP.
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PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells.
Issarang Nuchprayoon,Shari Meyers,Linda M. Scott,Joseph Suzow,Scott W. Hiebert,Alan D. Friedman +5 more
TL;DR: The myeloperoxidase (MPO) and neutrophil elastase genes are expressed specifically in immature myeloid cells and it is speculated that the resulting oncoproteins, AML1-ETO, AMl1-EAP, AM l1-evi1, and CBF beta-MYH11, inhibit early myeloids differentiation.
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Morphological Classification, Response to Therapy, and Survival in 263 Adult Patients With Acute Nonlymphoblastic Leukemia
Roland Mertelsmann,H. Tzvi Thaler,Lily To,Timothy Gee,S McKenzie,Peter K. Schauer,Alan D. Friedman,Zal Arlin,Constance Cirrincione,Bayard D. Clarkson +9 more
TL;DR: Bone marrow smears of 263 protocol patients with acute nonlymphoblastic leukemia and related disorders treated between 1970 and 1978 at MSKCC were reviewed blindly by two pairs of hematomorphologists and classified according to the FAB system, finding Auer rods to be the single most important prognostic parameter in this study.