Bayard D. Clarkson

TL;DR: The results suggest that compounds that exploit the distinctive inactivation mechanisms of individual protein kinases can achieve both high affinity and high specificity.

TL;DR: The crystal structure of the catalytic domain of the Abelson tyrosine kinase (Abl) complexed to a variant of STI-571 is reported in this paper.

TL;DR: The prognostic significance of disease features recorded at the time of diagnosis was examined among 813 patients with Philadelphia chromosome- positive, nonblastic chronic granulocytic leukemia (CGL) collected from six European and American series, and it should be possible to identify a lower risk group of patients with a 2-yr survival of 90%, subsequent risk averaging somewhat less than 20%/yr and median survival of 5 yr.

TL;DR: In this article, the authors report crystal structures of the kinase domain of Abl in complex with two small molecule inhibitors, imatinib (also known as STI-571 and Gleevec) and PD173955 (Parke-Davis).

TL;DR: It is demonstrated that rhG-CSF is a potent stimulus of normal neutrophil proliferation and maturation and its administration can reduce both the hematopoietic and oral toxicity of chemotherapy.