A
Alan Higbee
Researcher at University of Wisconsin-Madison
Publications - 22
Citations - 1469
Alan Higbee is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Hydrolysate & Corn stover. The author has an hindex of 14, co-authored 22 publications receiving 1257 citations. Previous affiliations of Alan Higbee include Michigan State University & Great Lakes Bioenergy Research Center.
Papers
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Journal ArticleDOI
Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome
Alexander S. Hebert,Kristin E. Dittenhafer-Reed,Wei Yu,Derek J. Bailey,Ebru Selin Selen,Melissa D. Boersma,Joshua J. Carson,Marco Tonelli,Allison J. Balloon,Alan Higbee,Michael S. Westphall,David J. Pagliarini,Tomas A. Prolla,Fariba M. Assadi-Porter,Sushmita Roy,John M. Denu,Joshua J. Coon +16 more
TL;DR: This work developed and applied a quantitative mass spectrometry method to probe the liver mitochondrial acetyl-proteome during CR versus control diet in mice that were wild-type or lacked the protein deacetylase SIRT3, and revealed widespread reprogramming of mitochondrial protein acetylation in response to CR.
Journal ArticleDOI
Cofermentation of glucose, xylose, and cellobiose by the beetle-associated yeast Spathaspora passalidarum.
Tanya M. Long,Yi-Kai Su,Yi-Kai Su,Jennifer R. Headman,Jennifer R. Headman,Alan Higbee,Laura B. Willis,Laura B. Willis,Laura B. Willis,Thomas W. Jeffries,Thomas W. Jeffries,Thomas W. Jeffries +11 more
TL;DR: Surprisingly, the ascomycetous, beetle-associated yeast Spathaspora passalidarum, which ferments xylose and cellobiose natively, can also coferment these two sugars in the presence of 30 g/liter glucose, making it very attractive for studying regulatory mechanisms enabling bioconversion of lignocellulosic materials by yeasts.
Journal ArticleDOI
Exploiting Natural Variation in Saccharomyces cerevisiae to Identify Genes for Increased Ethanol Resistance
TL;DR: This approach shows that comparative genomics across natural isolates can quickly identify genes for industrial engineering while expanding the understanding of natural diversity, by measuring acquired ethanol tolerance in a large panel of wild strains and showing that most strains can acquire higher tolerance after pretreatment.
Journal ArticleDOI
Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs.
TL;DR: It is shown that feeding CLA reduces lipid-derived inflammatory mediators produced by this type I hypersensitivity model, and decreased eicosanoid release from sensitized tissues in response to antigen challenge.
Book
Engineering and Two-Stage Evolution of a Lignocellulosic Hydrolysate-Tolerant Saccharomyces cerevisiae Strain for Anaerobic Fermentation of Xylose from AFEX Pretreated Corn Stover
Lucas S. Parreiras,Rebecca J. Breuer,Ragothaman Avanasi Narasimhan,Alan Higbee,Alex J. La Reau,Mary Tremaine,Li Qin,Laura B. Willis,Benjamin D. Bice,Brandi L. Bonfert,Rebeca C. Pinhancos,Allison J. Balloon,Nirmal Uppugundla,Tongjun Liu,Chenlin Li,Deepti Tanjore,Irene M. Ong,Haibo Li,Edward L. Pohlmann,Jose Serate,Sydnor T. Withers,Blake A. Simmons,David B. Hodge,Michael S. Westphall,Joshua J. Coon,Bruce E. Dale,Venkatesh Balan,David H. Keating,Yaoping Zhang,Robert Landick,Audrey P. Gasch,Trey K. Sato +31 more
TL;DR: The development of a xylose-fermenting S. cerevisiae strain with tolerance to a range of pretreated and hydrolyzed lignocellulose, including Ammonia Fiber Expansion-pretreated corn stover hydrolysate (ACSH) is described and results validate the combinatorial approach.