T
Tomas A. Prolla
Researcher at University of Wisconsin-Madison
Publications - 122
Citations - 19974
Tomas A. Prolla is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Mitochondrion & Mitochondrial DNA. The author has an hindex of 60, co-authored 119 publications receiving 18372 citations. Previous affiliations of Tomas A. Prolla include Wisconsin Alumni Research Foundation & Max Planck Society.
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Journal ArticleDOI
Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging
Gregory C. Kujoth,Asimina Hiona,Thomas D. Pugh,Shinichi Someya,K. Panzer,Stephanie E. Wohlgemuth,Tim Hofer,Arnold Y. Seo,R. Sullivan,Wendy A. Jobling,Jason D. Morrow,H. Van Remmen,John M. Sedivy,Tatsuya Yamasoba,Masaru Tanokura,Richard Weindruch,Christiaan Leeuwenburgh,Tomas A. Prolla +17 more
TL;DR: It is shown that mice expressing a proofreading-deficient version of the mitochondrial DNA polymerase g (POLG) accumulate mt DNA mutations and display features of accelerated aging, suggesting that accumulation of mtDNA mutations that promote apoptosis may be a central mechanism driving mammalian aging.
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Gene Expression Profile of Aging and Its Retardation by Caloric Restriction
TL;DR: Transcriptional patterns of calorie-restricted animals suggest that caloric restriction retards the aging process by causing a metabolic shift toward increased protein turnover and decreased macromolecular damage.
Journal ArticleDOI
SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
Marcia C. Haigis,Raul Mostoslavsky,Kevin M. Haigis,Kamau Fahie,Danos C. Christodoulou,Andrew J. Murphy,David M. Valenzuela,George D. Yancopoulos,Margaret Karow,Gil Blander,Cynthia Wolberger,Tomas A. Prolla,Richard Weindruch,Frederick W. Alt,Leonard Guarente +14 more
TL;DR: It is shown that SIRT4 functions in beta cell mitochondria to repress the activity of GDH by ADP-ribosylation, thereby downregulating insulin secretion in response to amino acids, effects that are alleviated during CR.
Journal ArticleDOI
Gene-expression profile of the ageing brain in mice.
TL;DR: Caloric restriction, which retards the ageing process in mammals, selectively attenuated the age-associated induction of genes encoding inflammatory and stress responses, which resulted in a gene-expression profile indicative of an inflammatory response, oxidative stress and reduced neurotrophic support in both brain regions.
Journal ArticleDOI
Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
Shinichi Someya,Shinichi Someya,Wei Yu,William C. Hallows,Jinze Xu,James M. Vann,Christiaan Leeuwenburgh,Masaru Tanokura,John M. Denu,Tomas A. Prolla +9 more
TL;DR: These findings suggest that Sirt3-dependent mitochondrial adaptations may be a central mechanism of aging retardation in mammals and suggest that CR reduces oxidative DNA damage in multiple tissues and prevents AHL in wild-type mice but fails to modify these phenotypes in mice lacking the mitochondrial deacetylase Sirt 3.