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Alan I. Faden
Researcher at University of Maryland, Baltimore
Publications - 437
Citations - 33238
Alan I. Faden is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Traumatic brain injury & Neuroprotection. The author has an hindex of 96, co-authored 433 publications receiving 30976 citations. Previous affiliations of Alan I. Faden include University of California, San Francisco & San Francisco VA Medical Center.
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Journal ArticleDOI
The role of excitatory amino acids and NMDA receptors in traumatic brain injury.
TL;DR: Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular glutamate and aspartate adjacent to the trauma site, which contributes to delayed tissue damage after brain trauma.
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Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury
Alexander G. Yakovlev,Susan M. Knoblach,Lei Fan,Gerard B. Fox,Randyll Goodnight,Alan I. Faden +5 more
TL;DR: Results implicate caspase-3-like proteases in neuronal apoptosis induced by TBI and suggest that the blockade of such caspases can reduce post-traumatic apoptosis and associated neurological dysfunction.
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Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies.
David J. Loane,Alan I. Faden +1 more
TL;DR: A critically review developing experimental neuroprotective strategies that show promise, and a criteria for improving the probability of successful clinical translation is proposed.
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MASCIS Evaluation of Open Field Locomotor Scores: Effects of Experience and Teamwork on Reliability
D M Basso,Michael S. Beattie,Jacqueline C. Bresnahan,Douglas K. Anderson,Alan I. Faden,J. A. Gruner,Theodore R. Holford,Chung Y. Hsu,Linda Noble,R. Nockels,Phanor L. Perot,Steven K. Salzman,Wise Young +12 more
TL;DR: Results indicate that inexperienced observers can learn quickly to assign consistent BBB scores that approach those given by experienced teams, that the scores are most consistent between 4 and 16, and that experience improves consistency of team scores.
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Naloxone reversal of endotoxin hypotension suggests role of endorphins in shock
John W. Holaday,Alan I. Faden +1 more
TL;DR: Using the specific opiate antagonist, naloxone, this work rapidly reversed endotoxin-induced hypotension, but also prophylactically blocked its occurrence and suggest that endorphins may have a role in the patho-physiology of shock and that narcotic antagonists should be evaluated for their potential therapeutic value in the treatment of shock.