Alan M. Carruthers

TL;DR: It is suggested that hypotension in the pithed rat may be a functional correlate of this site, and an enantiomeric selectivity favouring R‐ over S‐PIA are distinguishing features of the adenosine A3 receptor.

TL;DR: Elevated expression of a number of enzymes that can directly modulate the ECM has been reported, and recent data indicates that modulating the activity of these enzymes can have a downstream effect on fibrotic tissue remodeling.

TL;DR: A human ICAM-1 domain-1-specific antibody can prevent major group HRV entry and induction of airway inflammation in vivo, and reduce cellular inflammation, pro-inflammatory cytokine induction and virus load in vivo.

TL;DR: The present data confirm the PKA-dependence of forskolin-stimulated CGRP release and suggest that A(1) adenosine agonists may warrant further investigation in models of migraine and neurogenic inflammation.

TL;DR: It is demonstrated that the duration of activation and a critical balance between the mitogen-activated protein kinase and PI 3-K pathways are important for controlling cell proliferation and that the COOH termini of the sst2 receptor isoforms may determine the selection of appropriate βγ-pairings necessary for interaction with distinct kinase cascades.