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Alan M. Jeffrey
Researcher at Columbia University
Publications - 54
Citations - 2957
Alan M. Jeffrey is an academic researcher from Columbia University. The author has contributed to research in topics: Benzo(a)pyrene & Pyrene. The author has an hindex of 25, co-authored 54 publications receiving 2934 citations.
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Journal ArticleDOI
Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo.
I. B. Weinstein,Alan M. Jeffrey,K. W. Jennette,S. H. Blobstein,Ronald G. Harvey,Chris Harris,Herman Autrup,Hiroshi Kasai,Koji Nakanishi +8 more
TL;DR: Evidence has been obtained that a specific isomer of a diol epoxide derivative of benzo(a)pyrene, (+/-)-7 beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo( a)pyene, is an intermediate in the binding of benzos(a).pyrene to RNA in cultured bovine bronchial mucosa.
Journal ArticleDOI
Structures of benzo(a)pyrene–nucleic acid adducts formed in human and bovine bronchial explants
Alan M. Jeffrey,I. B. Weinstein,K. W. Jennette,K. Grzeskowiak,Koji Nakanishi,Ronald G. Harvey,Herman Autrup,Curtis C. Harris +7 more
TL;DR: Studies on RNA and DNA adducts formed by human bronchial explants are described and evidence that the structures of the majorAdducts are similar to those formed in the analogous bovine system is provided.
Journal ArticleDOI
Benzo[a]pyrene-nucleic acid derivative found in vivo: structure of a benzo[a]pyrenetetrahydrodiol epoxide-guanosine adduct
Alan M. Jeffrey,K. W. Jennette,S. H. Blobstein,I. B. Weinstein,F. A. Beland,Ronald G. Harvey,Hiroshi Kasai,Iwao Miura,Koji Nakanishi +8 more
Journal ArticleDOI
Nucleoside adducts from the in vitro reaction of benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide or benzo[a]pyrene 4,5-oxide with nucleic acids.
K. W. Jennette,Alan M. Jeffrey,S. H. Blobstein,F. A. Beland,Ronald G. Harvey,I. B. Weinstein +5 more
TL;DR: Alkaline or enzymatic hydrolysis of the modified nucleic acids and subsequent chromatography on Sephadex LH-20 columns yielded benzo[a]pyrene-nucleotide adducts which were enzymatically converted to the corresponding nucleosides which were resolved into several distinct components by high-pressure liquid chromatography.