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Showing papers by "Alan P. Kozikowski published in 2003"

Journal Article•DOI•
Functionalization of the alicyclic skeleton of epibatidine: synthesis and nicotinic acetylcholine receptor binding affinities of epibatidine analogues.

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Zhi Liang Wei1, Yingxian Xiao2, Clifford George3, Kenneth J. Kellar2, Alan P. Kozikowski1 •
University of Illinois at Chicago1, Georgetown University2, United States Naval Research Laboratory3
06 Nov 2003-Organic and Biomolecular Chemistry
TL;DR: In this article, a method for the epimerization of endo-2-(6-chloro-3pyridyl)-7-azabicyclo[2.2.1]heptan-3-one (12) on silica gel was developed and used as the key step to synthesize functionalized analogues of epibatidine which were evaluated for their nicotine receptor subtype selectivity in binding studies.
Abstract: A novel method for the epimerization of endo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptan-3-one (12) on silica gel was developed and used as the key step to synthesize functionalized analogues of epibatidine which were evaluated for their nicotine receptor subtype selectivity in binding studies.

11 citations