K
Kenneth J. Kellar
Researcher at Georgetown University
Publications - 142
Citations - 10664
Kenneth J. Kellar is an academic researcher from Georgetown University. The author has contributed to research in topics: Nicotinic agonist & Receptor. The author has an hindex of 50, co-authored 139 publications receiving 10506 citations. Previous affiliations of Kenneth J. Kellar include Johns Hopkins University School of Medicine.
Papers
More filters
Journal Article
A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.
TL;DR: The data indicate that alpha 4 and beta 2 subunits are associated with each other in at least one neuronal nicotinic receptor subtype that has high affinity for agonists and is significantly increased in the cortex of rats chronically treated with nicotine.
Journal Article
International Union of Pharmacology. XX. Current Status of the Nomenclature for Nicotinic Acetylcholine Receptors and Their Subunits
Ronald J. Lukas,Jean-Pierre Changeux,N. Le Novere,Edson X. Albuquerque,David J.K. Balfour,Darwin K. Berg,D. Bertrand,Vincent A. Chiappinelli,P. B. S. Clarke,Allan C. Collins,J. A. Dani,Sharon R. Grady,Kenneth J. Kellar,Jon Lindstrom,Michael J. Marks,Maryka Quik,Palmer Taylor,Susan Wonnacott +17 more
TL;DR: Nicotinic acetylcholine receptors in jawed vertebrates are prototypical members of the multisubunit, neurotransmitter-gated superfamily of ion channels (ionotropic neurotransmitter receptors; see Section IV for selected seminal papers, reviews, and collections).
Journal ArticleDOI
Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo
TL;DR: Saturation analysis of tritiated acetylcholine binding in the cortices of rats treated with diisopropyl fluorophosphate or nicotine indicated that the number of binding sites decreased and increased, respectively, while the affinity of the sites was unaltered.
Journal ArticleDOI
Nicotinic acetylcholine binding sites in Alzheimer's disease.
Peter J. Whitehouse,Andrea M. Martino,Piero Antuono,Pedro R. Lowenstein,Joseph T. Coyle,Donald L. Price,Kenneth J. Kellar +6 more
TL;DR: A consistent and severe loss of nicotinic receptors was found in AD and was similar to that found in patients with AD and matched controls.
Journal Article
Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies.
TL;DR: The increase in nicotinic receptors in the cerebral cortex and hippocampus of smokers may modify the central nervous system effects of nicotine and contribute to an altered response of smokers to nicotine.