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Alan P. Kozikowski
Researcher at University of Illinois at Chicago
Publications - 198
Citations - 11235
Alan P. Kozikowski is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Nicotinic agonist & Cancer. The author has an hindex of 55, co-authored 198 publications receiving 9996 citations. Previous affiliations of Alan P. Kozikowski include University of Chicago & University of Illinois at Urbana–Champaign.
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The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity
Nichole E. LaPointe,Gerardo Morfini,Gerardo Morfini,Gustavo Pigino,Gustavo Pigino,Irina N. Gaisina,Alan P. Kozikowski,Lester I. Binder,Scott T. Brady,Scott T. Brady +9 more
TL;DR: It is suggested that pathological tau aggregation contributes to neurodegeneration by altering a regulatory pathway for FAT in response to Alzheimer's disease and other tauopathies.
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NAAG peptidase inhibitors and their potential for diagnosis and therapy
TL;DR: This new class of compounds, of which at least one has entered clinical trials and proven to be well tolerated, has demonstrated efficacy in experimental models of pain, schizophrenia, amyotrophic lateral sclerosis, traumatic brain injury and, when appropriately functionalized, can image prostate cancer.
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Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.
TL;DR: A series of hydroxamate based HDAC inhibitors containing a phenylisoxazole as the CAP group has been synthesized using nitrile oxide cycloaddition chemistry, providing valuable, new molecular probes for use in exploring HDAC biology.
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Epigenetic Regulation of Autophagy by the Methyltransferase G9a
Amaia Artal Martinez de Narvajas,Timothy S. Gomez,Jin-San Zhang,Alexander O. Mann,Yoshiyuki Taoda,Jacquelyn A. Gorman,Marta Herreros-Villanueva,Thomas M. Gress,Volker Ellenrieder,Luis Bujanda,Do Hyung Kim,Alan P. Kozikowski,Alexander Koenig,Alexander Koenig,Daniel D. Billadeau +14 more
TL;DR: It is shown that the methyltransferase G9a coordinates the transcriptional activation of key regulators of autophagosome formation by remodeling the chromatin landscape and that inhibition of G9A-mediated epigenetic repression represents an important regulatory mechanism during autophagy.
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RI-1: A chemical inhibitor of RAD51 that disrupts Homologous recombination in human cells
Brian Budke,Hillary L. Logan,Jay H. Kalin,Anna Zelivianskaia,William Cameron McGuire,Luke L. Miller,Jeremy M. Stark,Alan P. Kozikowski,Douglas K. Bishop,Philip P. Connell +9 more
TL;DR: RI-1 is described, a small molecule that inhibits the central recombination protein RAD51 and specifically reduces gene conversion in human cells while stimulating single strand annealing and potentiates the lethal effects of a DNA cross-linking drug inhuman cells.