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Showing papers by "Alan R. Giles published in 2007"

Journal Article•DOI•
The formation of a Ca2+-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform

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Michael E. Nesheim1, John A. Samis1, John Walker1, Timothy Fischer2, Timothy Fischer3, Liliana Tejidor3, Greg Jones3, Wim P.M. Houdijk3, Alan R. Giles3, Lev Becker1, Marlys L. Koschinsky1, Richard Wenstone4, Colin Downey4, Cheng Hock Toh4 •
Queen's University1, Ventana Medical Systems2, Organon International3, Royal Liverpool University Hospital4
25 Jul 2007-BMC Pharmacology
TL;DR: A stepwise increase in the likelihood of mortality was directly correlated with the from 3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications Dresden, Germany.
Abstract: Clinical background The "biphasic transmittance waveform" (BTW) refers to a time-dependent decrease in light transmittance that often occurs prior to clotting when performing the activated partial thromboplastin time (aPTT) assay with plasmas of critically ill patients on the MDA® coagulation analyzer [1]. Early observations showed an association of the BTW with disseminated intravascular coagulation (DIC) and clinical outcome. (See Table 1) The magnitude of the BTW was assessed against in-patient mortality. A total of 346 patients were found to have a BTW on admission to the ITU with a mortality rate of 44%, as compared with 26% for those with normal waveforms. A stepwise increase in the likelihood of mortality was directly correlated with the from 3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications Dresden, Germany. 15–17 June 2007