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Colin Downey

Researcher at Royal Liverpool University Hospital

Publications -  39
Citations -  1519

Colin Downey is an academic researcher from Royal Liverpool University Hospital. The author has contributed to research in topics: Disseminated intravascular coagulation & Partial thromboplastin time. The author has an hindex of 19, co-authored 39 publications receiving 1225 citations. Previous affiliations of Colin Downey include BioMérieux & University of Liverpool.

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Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15-18 March 2016

Ryon M. Bateman, +1875 more
- 20 Apr 2016 - 
TL;DR: This research presents a novel probabilistic procedure called “spot-spot analysis” that allows for real-time analysis of the response of the immune system to natural disasters.
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Activated protein C induces the release of microparticle-associated endothelial protein C receptor.

TL;DR: A novel mechanism of endothelial protein C receptor (EPCR) release that is not inhibited by metalloproteinase inhibitors is demonstrated and could provide new insights into the consequences of APC therapy in the septic patient.
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Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca++-dependent complex of C-reactive protein with very-low–density lipoprotein and is a novel marker of impending disseminated intravascular coagulation

TL;DR: Clinically, the biphasic waveform (BPW) better predicts for DIC than either CRP or triglyceride alone and may have pathophysiological implications because CRP can be detected in the VLDL fraction from sera of patients with the BPW, and the V LDL fraction has enhanced prothrombinase surface activity.
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Assessment and clinical course of hypocalcemia in critical illness

TL;DR: Hypocalcemia usually normalizes within the first four days after admission to ICU and failure to normalize in severely hypocalcemic patients may be associated with increased mortality.