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Alana L. Rothman
Researcher at University of California, San Francisco
Publications - 5
Citations - 2626
Alana L. Rothman is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Patched & Basal Cell Nevus Syndrome. The author has an hindex of 5, co-authored 5 publications receiving 2549 citations.
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Journal ArticleDOI
Human Homolog of patched, a Candidate Gene for the Basal Cell Nevus Syndrome
Ronald L. Johnson,Alana L. Rothman,Jingwu Xie,Lisa V. Goodrich,John W. Bare,Jeannette M. Bonifas,Anthony G. Quinn,Richard M. Myers,David R. Cox,Ervin H. Epstein,Matthew P. Scott +10 more
TL;DR: Heritable mutations in BCNS patients and a somatic mutation in a sporadic BCC were identified in a human homolog of the Drosophila patched (ptc) gene, which appears to be crucial for proper embryonic development and for tumor suppression.
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Epidermolysis bullosa simplex: evidence in two families for keratin gene abnormalities
TL;DR: In one family studied, inheritance of EBS is linked to the gene encoding keratin 14, and a thymine to cytosine mutation in exon 6 of keratin14 has introduced a proline in the middle of an alpha-helical region.
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Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome
Michelle Aszterbaum,Alana L. Rothman,Ronald L. Johnson,Monte P. Fisher,Jingwu Xie,Jeannette M. Bonifas,Xioli Zhang,Mathew P. Scott,Ervin H. Epstein +8 more
TL;DR: Results provide further evidence for the crucial role of PTC as a tumor suppressor in human keratinocytes and the most common mutations were frameshifts resulting in premature chain termination.
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A high resolution physical map of 2.5 Mbp of the Down syndrome region on chromosome 21.
Nila Patil,Andrew S. Peterson,Alana L. Rothman,Pieter J. de Jong,Richard M. Myers,David R. Cox +5 more
TL;DR: A high resolution map of a 2.5 Mb region around the marker D21S55 of human chromosome 21 is constructed and provides the framework for further analysis of the region by transcribed sequence mapping and sequence determination.
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Herpes virus infection of RPE and MDCK cells: Polarity of infection
TL;DR: Whether herpes simplex virus infects preferentially the apical or basolateral surfaces of two well-differentiated cell types, human retinal pigment epithelial cell and Madin-Darby canine kidney epithelial cells, is determined and evidence is consistent with the hypothesis that the virus may utilize the mannose 6-phosphate/insulin-like growth factor II receptor to facilitate entry.