E
Ervin H. Epstein
Researcher at Children's Hospital Oakland Research Institute
Publications - 231
Citations - 17911
Ervin H. Epstein is an academic researcher from Children's Hospital Oakland Research Institute. The author has contributed to research in topics: Basal cell carcinoma & Hedgehog signaling pathway. The author has an hindex of 56, co-authored 231 publications receiving 17200 citations. Previous affiliations of Ervin H. Epstein include University of California, San Francisco & San Francisco General Hospital.
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Journal ArticleDOI
Human Homolog of patched, a Candidate Gene for the Basal Cell Nevus Syndrome
Ronald L. Johnson,Alana L. Rothman,Jingwu Xie,Lisa V. Goodrich,John W. Bare,Jeannette M. Bonifas,Anthony G. Quinn,Richard M. Myers,David R. Cox,Ervin H. Epstein,Matthew P. Scott +10 more
TL;DR: Heritable mutations in BCNS patients and a somatic mutation in a sporadic BCC were identified in a human homolog of the Drosophila patched (ptc) gene, which appears to be crucial for proper embryonic development and for tumor suppression.
Journal ArticleDOI
Activating Smoothened mutations in sporadic basal-cell carcinoma.
Jingwu Xie,Jingwu Xie,Maximilien Murone,Shiuh Ming Luoh,Anne M. Ryan,Qimin Gu,Chaohui Zhang,Jeannette M. Bonifas,Jeannette M. Bonifas,Ching-Wan Lam,Mary Hynes,Audrey Goddard,Arnon Rosenthal,Ervin H. Epstein,Ervin H. Epstein,Frederic J. de Sauvage +15 more
TL;DR: Findings support the role of SMO as a signalling component of the SHH–receptor complex and provide direct evidence that mutated SMO can function as an oncogene in BCCs.
Journal ArticleDOI
Basal cell carcinomas: attack of the hedgehog
TL;DR: A phase 1 first-in-human trial of a Hedgehog inhibitor has shown real progress in halting and even reversing the growth of BCCs.
Journal ArticleDOI
Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog
Anthony E. Oro,Kay M. Higgins,Kay M. Higgins,Zhilan Hu,Zhilan Hu,Jeannette M. Bonifas,Jeannette M. Bonifas,Ervin H. Epstein,Ervin H. Epstein,Matthew P. Scott,Matthew P. Scott +10 more
TL;DR: It is shown here that transgenic mice overexpressing SHH in the skin develop many features of basal cell nevus syndrome, demonstrating that SHH is sufficient to induce basal cell carcinomas in mice, suggesting thatSHH may have a role in human tumorigenesis.
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[α1(III)]3 Human Skin Collagen RELEASE BY PEPSIN DIGESTION AND PREPONDERANCE IN FETAL LIFE
TL;DR: The relative quantities of these peptides indicate that α1(III) chains predominate in early fetal skin, but by birth and in later lifeα1(I) chains are approximately 3 times as plentiful.