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Alastair J. Flint

Researcher at University of Toronto

Publications -  158
Citations -  4156

Alastair J. Flint is an academic researcher from University of Toronto. The author has contributed to research in topics: Psychotic depression & Medicine. The author has an hindex of 33, co-authored 128 publications receiving 3528 citations. Previous affiliations of Alastair J. Flint include Toronto Rehabilitation Institute & University Health Network.

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Journal ArticleDOI

Anhedonia and Reward-Circuit Connectivity Distinguish Nonresponders from Responders to Dorsomedial Prefrontal Repetitive Transcranial Magnetic Stimulation in Major Depression

Jonathan Downar, +14 more
- 01 Aug 2014 - 
TL;DR: Two distinct depression subtypes are suggested, one with preserved hedonic function and responsive to dorsomedial rTMS and another with disrupted hedono-reward circuit integrity, abnormally lateralized connectivity through ventromedial prefrontal cortex, and unresponsive to dorsifiedial RTMS.
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Resting-State Cortico-Thalamic-Striatal Connectivity Predicts Response to Dorsomedial Prefrontal rTMS in Major Depressive Disorder

Tim V. Salomons, +6 more
- 01 Jan 2014 - 
TL;DR: It is found that successful treatment was associated with increased dmPFC-thalamic connectivity and decreased subgenual cingulate cortex-caudate connectivity, which provides insight into which individuals might respond to rTMS treatment and the mechanisms through which these treatments work.
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The complex interplay of depression and falls in older adults: a clinical review

Andrea Iaboni, +2 more
- 01 Apr 2012 - 
TL;DR: Exercise (particularly Tai Chi) and cognitive-behavioral therapy should be considered for the first-line treatment of mild depression in older fallers, and Antidepressant medications are indicated to treat moderate to severe depression in fall-prone individuals, but with appropriate precautions.
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Elevation of Prolactin Levels by Atypical Antipsychotics

Peter Turrone, +3 more
- 01 Jan 2002 - 
TL;DR: Data suggest that these atypical antipsychotics raise prolactin levels, although the increases with olanzapine did not reach statistical significance.
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A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD)

Barnett S. Meyers, +10 more
- 01 Aug 2009 - 
TL;DR: Combination pharmacotherapy is efficacious for the treatment of MD with psychotic features and future research must determine the benefits vs risks of continuing atypical antipsychotic medications beyond 12 weeks.