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Alastair J. Florence
Researcher at Strathclyde Institute of Pharmacy and Biomedical Sciences
Publications - 192
Citations - 4356
Alastair J. Florence is an academic researcher from Strathclyde Institute of Pharmacy and Biomedical Sciences. The author has contributed to research in topics: Crystal structure & Crystallization. The author has an hindex of 36, co-authored 180 publications receiving 3723 citations. Previous affiliations of Alastair J. Florence include Engineering and Physical Sciences Research Council & University of Strathclyde.
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A strategy for producing predicted polymorphs: catemeric carbamazepine form V
TL;DR: A computationally assisted approach has enabled the first catemeric polymorph of carbamazepine (form V) to be selectively formed by templating the growth of carbazepine from the vapour phase onto the surface of a crystal of dihydrocarbamazepines form II.
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Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization
Thomas McGlone,Naomi E. B. Briggs,Catriona A. Clark,Cameron J. Brown,Jan Sefcik,Alastair J. Florence +5 more
TL;DR: Oscillatory flow reactors (OFRs) offer a suitable platform to deliver consistent operating conditions under plug-flow operation while maintaining a controlled steady state as discussed by the authors, which is an attractive approach for the delivery of consistent particles with specified critical quality attributes (CQAs).
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Achieving Continuous Manufacturing: Technologies and Approaches for Synthesis, Workup, and Isolation of Drug Substance May 20–21, 2014 Continuous Manufacturing Symposium
Ian R. Baxendale,Richard D. Braatz,Benjamin K. Hodnett,Klavs F. Jensen,Martin D. Johnson,Paul N. Sharratt,Jon-Paul Sherlock,Alastair J. Florence +7 more
TL;DR: The cultural, as well as skills and training, challenges that will need to be met by support from organizations in order to accommodate the new work flows are addressed.
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Exploring the Experimental and Computed Crystal Energy Landscape of Olanzapine
Rajni M. Bhardwaj,Louise S. Price,Sarah L. Price,Susan M. Reutzel-Edens,Gary J. Miller,Iain D. H. Oswald,Blair F. Johnston,Alastair J. Florence +7 more
TL;DR: In this paper, an extensive experimental search for solid forms of the antipsychotic compound olanzapine identified 60 distinct solid forms including three nonsolvated polymorphs, 56 crystalline solvates, and an amorphous phase.
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A single-crystal neutron diffraction study of the temperature dependence of hydrogen-atom disorder in benzoic acid dimers
TL;DR: In this paper, a series of neutron single-crystal structure refinements at five temperatures ranging from 175 K, where Arrhenius behaviour holds, down to 20 K where translational tunnelling is dominant.