Alastair Lockwood

TL;DR: This survey shows that good trabeculectomy outcomes with low rates of surgical complications can be achieved, but intensive proactive postoperative care is required.

TL;DR: The least invasive routes for ocular drug administration are topical (e.g. eyedrops) and systemic formulations as discussed by the authors, however, topical drugs often display limited bioavailability due to many physical and biochemical barriers including the pre-corneal tear film, the structure and biophysiologic properties of the cornea, the limited volume that can be accommodated by the cul-desac, the lacrimal drainage system and reflex tearing.

TL;DR: Preoperative, intraoperative and postoperative strategies, which improve the outcome of GFS, are covered, which have considerably reduced the incidence of major complications including hypotony, cystic blebs and endophthalmitis in practices around the world.

TL;DR: Drug delivery to the posterior segment is a greater challenge and, currently, the standard route is via intravitreal injection, notwithstanding the risks of endophthalmitis and retinal detachment with frequent injections.

TL;DR: Results indicate that the 2-compartment in vitro eye flow model can be used to determine in vitro-in vivo correlations in preclinical studies to develop long-lasting therapeutics to treat blinding diseases at the back of the eye.