Institution
Queen Alexandra Hospital
Healthcare•Portsmouth, United Kingdom•
About: Queen Alexandra Hospital is a healthcare organization based out in Portsmouth, United Kingdom. It is known for research contribution in the topics: Population & Cancer. The organization has 2299 authors who have published 2592 publications receiving 60211 citations. The organization is also known as: QA Hospital.
Topics: Population, Cancer, Medicine, Intensive care, Health care
Papers published on a yearly basis
Papers
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University Hospitals Birmingham NHS Foundation Trust1, University of Warwick2, University of Salford3, Cardiff University4, Institute of Cancer Research5, Beatson West of Scotland Cancer Centre6, Leeds Teaching Hospitals NHS Trust7, Weston Park Hospital8, Maidstone Hospital9, Royal Bournemouth Hospital10, Derby Hospitals NHS Foundation Trust11, Guy's Hospital12, Cheltenham General Hospital13, Queen Alexandra Hospital14, The Queen's Medical Center15, Musgrove Park Hospital16, Hull and East Yorkshire Hospitals NHS Trust17, Mount Vernon Hospital18, Royal Surrey County Hospital19, East Sussex County Council20, Western General Hospital21, Queen's University Belfast22, East Lancashire Hospitals NHS Trust23, Churchill Hospital24, Telford25, Royal Devon and Exeter Hospital26, Nottingham University Hospitals NHS Trust27, Clatterbridge Cancer Centre NHS Foundation Trust28, Swansea University29
TL;DR: Zoledronic acid showed no evidence of survival improvement and should not be part of standard of care for this population of men, and heterogeneity in treatment effect across prespecified subsets was not found.
1,502 citations
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TL;DR: The current summary of the EAU Muscle- invasive and Metastatic Bladder Cancer Guidelines provides an up-to-date overview of the available literature and evidence dealing with diagnosis, treatment, and follow-up of patients with metastatic and muscle-invasive bladder cancer.
1,209 citations
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TL;DR: The hypothesis was that arthroscopic repair of full-thickness supraspinatus tears achieves a rate of complete tendon healing equivalent to those reported in the literature with open or mini-open techniques.
Abstract: Background: Good functional results have been reported for arthroscopic repair of rotator cuff tears, but the rate of tendon-to-bone healing is still unknown. Our hypothesis was that arthroscopic repair of full-thickness supraspinatus tears achieves a rate of complete tendon healing equivalent to those reported in the literature with open or mini-open techniques.
Methods: Sixty-five consecutive shoulders with a chronic full-thickness supraspinatus tear were repaired arthroscopically in sixty-five patients with use of a tension-band suture technique. Patients ranged in age from twenty-nine to seventy-nine years. The average duration of follow-up was twenty-nine months. Fifty-one patients (fifty-one shoulders) had a computed tomographic arthrogram, and fourteen had a magnetic resonance imaging scan, performed between six months and three years after surgery. All patients were assessed with regard to function and the strength of the shoulder elevation.
Results: The rotator cuff was completely healed and watertight in forty-six (71%) of the sixty-five patients and was partially healed in three. Although the supraspinatus tendon did not heal to the tuberosity in sixteen shoulders, the size of the persistent defect was smaller than the initial tear in fifteen. Sixty-two of the sixty-five patients were satisfied with the result. The Constant score improved from an average (and standard deviation) of 51.6 ± 10.6 points preoperatively to 83.8 ± 10.3 points at the time of the last follow-up evaluation (p < 0.001), and the average University of California at Los Angeles score improved from 11.5 ± 1.1 to 32.3 ± 1.3 (p < 0.001). The average strength of the shoulder elevation was significantly better (p = 0.001) when the tendon had healed (7.3 ± 2.9 kg) than when it had not (4.7 ± 1.9 kg). Factors that were negatively associated with tendon healing were increasing age and associated delamination of the subscapularis or infraspinatus tendon. Only ten (43%) of twenty-three patients over the age of sixty-five years had completely healed tendons (p < 0.001).
Conclusions: Arthroscopic repair of an isolated supraspinatus detachment commonly leads to complete tendon healing. The absence of healing of the repaired rotator cuff is associated with inferior strength. Patients over the age of sixty-five years (p = 0.001) and patients with associated delamination of the subscapularis and/or the infraspinatus (p = 0.02) have significantly lower rates of healing.
Level of Evidence: Therapeutic Level IV. See Instructions to Authors for a complete description of levels of evidence.
1,191 citations
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Charles University in Prague1, Pierre-and-Marie-Curie University2, Medical University of Graz3, European Association of Urology4, University of Regensburg5, Queen Alexandra Hospital6, Netherlands Cancer Institute7, Royal Surrey County Hospital8, Autonomous University of Barcelona9, Medical University of Vienna10
TL;DR: The European Association of Urology (EAU) Guidelines Panel on Upper Urinary Tract Urothelial Carcinoma (UTUC) as mentioned in this paper provided updated guidelines to aid clinicians in the current evidence-based management of UTUC and to incorporate recommendations into clinical practice.
1,161 citations
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University of Cambridge1, Nottingham University Hospitals NHS Trust2, University of Manchester3, St George's Hospital4, University of Southampton5, University of Warwick6, Cambridge University Hospitals NHS Foundation Trust7, University of Oxford8, Queen Alexandra Hospital9, University of Plymouth10, Northumbria Healthcare NHS Foundation Trust11, University of Nottingham12, University Hospital Coventry13, King's College London14, McMaster University15, University of Leicester16
TL;DR: These guidelines provide a practical and evidence-based resource for the management of patients with Barrett's oesophagus and related early neoplasia and suggested stratification of patients according to their estimated cancer risk based on clinical and histopathological criteria for the first time.
Abstract: These guidelines provide a practical and evidence-based resource for the management of patients with Barrett's oesophagus and related early neoplasia. The Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument was followed to provide a methodological strategy for the guideline development. A systematic review of the literature was performed for English language articles published up until December 2012 in order to address controversial issues in Barrett's oesophagus including definition, screening and diagnosis, surveillance, pathological grading for dysplasia, management of dysplasia, and early cancer including training requirements. The rigour and quality of the studies was evaluated using the SIGN checklist system. Recommendations on each topic were scored by each author using a five-tier system (A+, strong agreement, to D+, strongly disagree). Statements that failed to reach substantial agreement among authors, defined as >80% agreement (A or A+), were revisited and modified until substantial agreement (>80%) was reached. In formulating these guidelines, we took into consideration benefits and risks for the population and national health system, as well as patient perspectives. For the first time, we have suggested stratification of patients according to their estimated cancer risk based on clinical and histopathological criteria. In order to improve communication between clinicians, we recommend the use of minimum datasets for reporting endoscopic and pathological findings. We advocate endoscopic therapy for high-grade dysplasia and early cancer, which should be performed in high-volume centres. We hope that these guidelines will standardise and improve management for patients with Barrett's oesophagus and related neoplasia.
1,083 citations
Authors
Showing all 2304 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gerald F. Watts | 100 | 889 | 43807 |
Richard W Morris | 91 | 519 | 35165 |
Gavin D. Perkins | 74 | 579 | 27562 |
Snehal G. Patel | 73 | 367 | 16905 |
Martin E.M. Noble | 65 | 155 | 16018 |
Adrian P. Banning | 65 | 487 | 22207 |
David H. Birnie | 58 | 301 | 12675 |
Hemant Pandit | 56 | 392 | 13122 |
Peter Griffiths | 55 | 342 | 13658 |
Ian A. Cree | 53 | 203 | 9644 |
Jonathan Ian Bisson | 50 | 199 | 11343 |
Federica Di Nicolantonio | 49 | 135 | 17985 |
Gary B. Smith | 49 | 233 | 14263 |
Angela M. Wood | 47 | 178 | 22224 |
Dennis K. Pearl | 45 | 148 | 11956 |