A
Albert Härtl
Researcher at Leibniz Association
Publications - 18
Citations - 1337
Albert Härtl is an academic researcher from Leibniz Association. The author has contributed to research in topics: Virulence & Corpus albicans. The author has an hindex of 16, co-authored 18 publications receiving 1238 citations.
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The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus.
Márcia Eliana da Silva Ferreira,Marcia Regina von Zeska Kress,Marcela Savoldi,Maria Helena S. Goldman,Albert Härtl,Thorsten Heinekamp,Axel A. Brakhage,Gustavo H. Goldman +7 more
TL;DR: To increase the frequency of homologous recombination, the KU80 homologue in Aspergillus fumigatus was inactivated and deletion had no influence on pathogenicity in a low-dose murine infection model.
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Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model
Claudio Kupfahl,Thorsten Heinekamp,Gernot Geginat,Thomas Ruppert,Albert Härtl,Herbert Hof,Axel A. Brakhage +6 more
TL;DR: Gliotoxin is not required for pathogenicity of the fungus in immunocompromised mice, despite the fact that a reduced cytotoxicity of the culture supernatant of gliP deletion strains was demonstrated.
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The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response
Vito Valiante,Thorsten Heinekamp,Thorsten Heinekamp,Radhika Jain,Radhika Jain,Albert Härtl,Axel A. Brakhage,Axel A. Brakhage +7 more
TL;DR: The analysis of mpkA deletion mutants revealed severe sensitivity of the mutants against cell wall active compounds, drastical alterations of the fungal morphology and increased resistance against oxidative stress.
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Functional characterization of the Aspergillus fumigatus calcineurin.
Márcia Eliana da Silva Ferreira,Thorsten Heinekamp,Albert Härtl,Axel A. Brakhage,Camile P. Semighini,Steven D. Harris,Marcela Savoldi,Paula Fagundes de Gouvêa,Maria Helena S. Goldman,Gustavo H. Goldman +9 more
TL;DR: Results suggest that calcineurin is involved in the regulation of the PHO pathway in A. fumigatus and opens new venues for the research on sensing and nutrient acquisition in this fungus.
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A multicopper oxidase gene from Candida albicans: cloning, characterization and disruption.
TL;DR: The null mutant strain showed no change in pathogenicity compared with the wild-type strain in the mouse model of systemic candidiasis and the deduced amino acid sequences of CaFET3 and the Saccharomyces cerevisiae FET3 gene are 55%.