Albert Härtl

TL;DR: The Abr2 laccase was characterised and it was shown that the polyketide synthase encoded by the pksP (alb1) gene represents a virulence determinant and the Δabr2 mutant strain showed no reduction in virulence compared with the wild type.

TL;DR: The V-ATPase subunit Vma7p is involved in vacuolar ion transport and this transport is required for hyphal growth and virulence of C. albicans, which results in reduced vacuole acidification and defects in degradation of intravacuolar putative endosomal structures.

TL;DR: The fungus Daedalea quercina (oak mazegill) was examined for its capability of producing antioxidative and anti-inflammatory compounds and the isolation of quercinol was identified as (-)-(2S)-2-hydroxymethyl-2-methyl-6-hydroxychromene 1 by NMR and X-ray analyses.

TL;DR: The results suggest that CaVPS34 may serve as a potential target for antifungal drugs as it was shown to be avirulent in a mouse model of systemic infection.

TL;DR: Thiosemicarbazones of the microbial metabolite madurahydroxylactone, a polysubstituted benzo[a]naphthacenequinone, have been reported by us as potent nonsteroidal inhibitors of the enzyme estrone sulfatase and showed low acute toxicity in the hen's fertile egg screening test.