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Albert P. Chen
Researcher at GE Healthcare
Publications - 103
Citations - 6301
Albert P. Chen is an academic researcher from GE Healthcare. The author has contributed to research in topics: Magnetic resonance spectroscopic imaging & Pyruvic acid. The author has an hindex of 36, co-authored 101 publications receiving 5762 citations. Previous affiliations of Albert P. Chen include University of California, San Francisco.
Papers
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Journal ArticleDOI
Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate
Sarah J. Nelson,John Kurhanewicz,Daniel B. Vigneron,Peder E. Z. Larson,Andrea L. Harzstark,Marcus Ferrone,Mark Van Criekinge,Jose W. Chang,Robert Bok,Ilwoo Park,Galen D. Reed,Lucas Carvajal,Eric J. Small,Pamela N. Munster,Vivian Weinberg,Jan Henrik Ardenkjær-Larsen,Albert P. Chen,Ralph E. Hurd,Liv-Ingrid Odegardstuen,Fraser Robb,James Tropp,Jonathan Alan Murray +21 more
TL;DR: This first-in-man imaging study evaluated the safety and feasibility of hyperpolarized [1-13C]pyruvate as an agent for noninvasively characterizing alterations in tumor metabolism for patients with prostate cancer and showed elevated levels of lactate, alanine, and bicarbonate in regions of biopsy-proven cancer.
Journal ArticleDOI
Hyperpolarized 13C Lactate, Pyruvate, and Alanine: Noninvasive Biomarkers for Prostate Cancer Detection and Grading
Mark J. Albers,Robert Bok,Albert P. Chen,Charles H. Cunningham,Matt L. Zierhut,Vickie Zhang,Susan J. Kohler,James Tropp,Ralph E. Hurd,Yi-Fen Yen,Sarah J. Nelson,Daniel B. Vigneron,John Kurhanewicz +12 more
TL;DR: Elevated hyperpolarized lactate and potentially THC and alanine are noninvasive biomarkers of prostate cancer presence and histologic grade that could be used in future three-dimensional (13)C spectroscopic imaging studies of prostatecancer patients.
Journal ArticleDOI
Hyperpolarized 13C Metabolic MRI of the Human Heart: Initial Experience
Charles H. Cunningham,Justin Y. C. Lau,Albert P. Chen,Benjamin J. Geraghty,William J. Perks,Idan Roifman,Graham A. Wright,Kim A. Connelly +7 more
TL;DR: In this paper, a noninvasive method for imaging metabolic markers that could be used in longitudinear environments was proposed, which can be used to diagnose heart failure in patients.
Journal ArticleDOI
Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T—Initial experience
Albert P. Chen,Mark J. Albers,Charles H. Cunningham,Charles H. Cunningham,Susan J. Kohler,Yi-Fen Yen,Ralph E. Hurd,James Tropp,Robert Bok,John M. Pauly,Sarah J. Nelson,John Kurhanewicz,Daniel B. Vigneron +12 more
TL;DR: Elevated 13C lactate was observed in both primary and metastatic tumors, demonstrating the feasibility of studying cellular bioenergetics in vivo with DNP hyperpolarized 13C MRSI.
Journal ArticleDOI
In vivo 13 carbon metabolic imaging at 3T with hyperpolarized 13C-1-pyruvate.
Susan J. Kohler,Yi-Fen Yen,Jan Wolber,Albert P. Chen,Mark J. Albers,Robert Bok,Vickie Zhang,James Tropp,Sarah J. Nelson,Daniel B. Vigneron,John Kurhanewicz,Ralph E. Hurd +11 more
TL;DR: Dynamic spectra and spectroscopic images acquired in normal rats at 3T following the injection of 13C‐1‐pyruvate that was hyperpolarized by the dynamic nuclear polarization (DNP) method are presented for the first time.