Institution
GE Healthcare
Company•Madrid, Spain•
About: GE Healthcare is a company organization based out in Madrid, Spain. It is known for research contribution in the topics: Imaging phantom & Iterative reconstruction. The organization has 4181 authors who have published 6324 publications receiving 156358 citations. The organization is also known as: GE Medical Systems.
Topics: Imaging phantom, Iterative reconstruction, Image quality, Magnetic resonance imaging, Population
Papers published on a yearly basis
Papers
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TL;DR: In a series of 51 patients with chest CT and real-time polymerase chain reaction assay (RT-PCR) performed within 3 days, the sensitivity of CT for 2019 novel coronavirus infection was 98% and that ...
Abstract: In a series of 51 patients with chest CT and real-time polymerase chain reaction assay (RT-PCR) performed within 3 days, the sensitivity of CT for 2019 novel coronavirus infection was 98% and that ...
2,714 citations
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TL;DR: The method can be used generally for signal enhancement and reduction of measurement time in liquid-state NMR and opens up for a variety of in vitro and in vivo applications of DNP-enhanced NMR.
Abstract: A method for obtaining strongly polarized nuclear spins in solution has
been developed. The method uses low temperature, high magnetic field, and
dynamic nuclear polarization (DNP) to strongly polarize nuclear spins in the
solid state. The solid sample is subsequently dissolved rapidly in a suitable
solvent to create a solution of molecules with hyperpolarized nuclear spins.
The polarization is performed in a DNP polarizer, consisting of a
super-conducting magnet (3.35 T) and a liquid-helium cooled sample space. The
sample is irradiated with microwaves at ≈94 GHz. Subsequent to
polarization, the sample is dissolved by an injection system inside the DNP
magnet. The dissolution process effectively preserves the nuclear
polarization. The resulting hyperpolarized liquid sample can be transferred to
a high-resolution NMR spectrometer, where an enhanced NMR signal can be
acquired, or it may be used as an agent for in vivo imaging or
spectroscopy. In this article we describe the use of the method on aqueous
solutions of [ 13 C]urea. Polarizations of 37% for 13 C and
7.8% for 15 N, respectively, were obtained after the dissolution.
These polarizations correspond to an enhancement of 44,400 for 13 C
and 23,500 for 15 N, respectively, compared with thermal equilibrium
at 9.4 T and room temperature. The method can be used generally for signal
enhancement and reduction of measurement time in liquid-state NMR and opens up
for a variety of in vitro and in vivo applications of
DNP-enhanced NMR.
2,508 citations
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15 Jun 1999TL;DR: In this article, the authors present a review of the properties of a single Nucleus to a magnetic field and its properties in the context of MR imaging, which includes the following: Magnetic Field Inhomogeneity effects and T-2 Dephasing.
Abstract: Magnetic Resonance Imaging: A Preview. Classical of a Single Nucleus to a Magnetic Field. Rotating Reference Frames and Resonance. Magnetization, Relaxation and the Bloch Equation. The Quantum Mechanical Basis of Precession and Excitation. The Quantum Mechanical Basis of Thermal Equilibrium and Longitudinal Relaxation. Signal Detection Concepts. Introductory Signal Acquisition Methods: Free Induction Decay, Spin Echoes, Inversion Recovery and Spectroscopy. One-Dimensional Fourier Imaging, k-Space and Gradient Echoes. Multi-Dimensional Fourier Imaging and Slice Excitation. The Continuous and Discrete Fourier Transforms. Sampling and Aliasing in Image Reconstruction. Filtering and Resolution in Fourier Transform Image Reconstruction. Projection Reconstruction of Images. Signal, Contrast and Noise. A Closer Look at Radiofrequency Pulses. Water/Fat Separation Techniques. Fast Imaging in the Steady State. Segmented k-Space and Echo Planar Imaging. Magnetic Field Inhomogeneity Effects and T-2 Dephasing. Random Walks, Relaxation and Diffusion. Spin Density, T-1 and T-2 Quantification Methods in MR Imaging. Motion Artifacts and Flow Compensation. MR Angiography and Flow Quantification. Magnetic Properties of Tissues: Theory and Measurement. Sequence Design, Artifacts and Nomenclature. Introduction to MRI Coils and Magnets. Appendices. Index.
2,140 citations
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Food and Drug Administration1, GE Healthcare2, Thermo Fisher Scientific3, Illumina4, Agilent Technologies5, National Institutes of Health6, Applied Biosystems7, University of Toledo8, Stratagene9, United States Environmental Protection Agency10, University of Massachusetts Boston11, Clinical Data, Inc12, University of California, Los Angeles13, SAS Institute14, Biogen Idec15, Yale University16, Cold Spring Harbor Laboratory17, Discovery Institute18, Stanford University19, Harvard University20, Vanderbilt University21, University of Texas at Dallas22, University of Oslo23, Novartis24, University of Texas MD Anderson Cancer Center25, Luminex Corporation26, Wake Forest University27, University of Illinois at Urbana–Champaign28
TL;DR: This study describes the experimental design and probe mapping efforts behind the MicroArray Quality Control project and shows intraplatform consistency across test sites as well as a high level of interplatform concordance in terms of genes identified as differentially expressed.
Abstract: Over the last decade, the introduction of microarray technology has had a profound impact on gene expression research. The publication of studies with dissimilar or altogether contradictory results, obtained using different microarray platforms to analyze identical RNA samples, has raised concerns about the reliability of this technology. The MicroArray Quality Control (MAQC) project was initiated to address these concerns, as well as other performance and data analysis issues. Expression data on four titration pools from two distinct reference RNA samples were generated at multiple test sites using a variety of microarray-based and alternative technology platforms. Here we describe the experimental design and probe mapping efforts behind the MAQC project. We show intraplatform consistency across test sites as well as a high level of interplatform concordance in terms of genes identified as differentially expressed. This study provides a resource that represents an important first step toward establishing a framework for the use of microarrays in clinical and regulatory settings.
1,987 citations
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University of Chicago1, Roy J. and Lucille A. Carver College of Medicine2, University of Texas MD Anderson Cancer Center3, University of California, Los Angeles4, University of Michigan5, Cornell University6, Memorial Sloan Kettering Cancer Center7, Icahn School of Medicine at Mount Sinai8, National Institute of Standards and Technology9, University of Pittsburgh10, Food and Drug Administration11, Science Applications International Corporation12, Agfa-Gevaert13, iCAD Inc.14, Carestream Health15, Philips16, Siemens17, GE Healthcare18
TL;DR: The goal of this process was to identify as completely as possible all lung nodules in each CT scan without requiring forced consensus and is expected to provide an essential medical imaging research resource to spur CAD development, validation, and dissemination in clinical practice.
Abstract: Purpose: The development of computer-aided diagnostic (CAD) methods for lung nodule detection, classification, and quantitative assessment can be facilitated through a well-characterized repository of computed tomography (CT) scans. The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI) completed such a database, establishing a publicly available reference for the medical imaging research community. Initiated by the National Cancer Institute (NCI), further advanced by the Foundation for the National Institutes of Health (FNIH), and accompanied by the Food and Drug Administration (FDA) through active participation, this public-private partnership demonstrates the success of a consortium founded on a consensus-based process. Methods: Seven academic centers and eight medical imaging companies collaborated to identify, address, and resolve challenging organizational, technical, and clinical issues to provide a solid foundation for a robust database. The LIDC/IDRI Database contains 1018 cases, each of which includes images from a clinical thoracic CT scan and an associated XML file that records the results of a two-phase image annotation process performed by four experienced thoracic radiologists. In the initial blinded-read phase, each radiologist independently reviewed each CT scan and marked lesions belonging to one of three categories (" nodule�3 mm," " nodule<3 mm," and "non- nodule�3 mm "). In the subsequent unblinded-read phase, each radiologist independently reviewed their own marks along with the anonymized marks of the three other radiologists to render a final opinion. The goal of this process was to identify as completely as possible all lung nodules in each CT scan without requiring forced consensus. Results: The Database contains 7371 lesions marked "nodule" by at least one radiologist. 2669 of these lesions were marked " nodul�3 mm " by at least one radiologist, of which 928 (34.7) received such marks from all four radiologists. These 2669 lesions include nodule outlines and subjective nodule characteristic ratings. Conclusions: The LIDC/IDRI Database is expected to provide an essential medical imaging research resource to spur CAD development, validation, and dissemination in clinical practice. © 2011 U.S. Government.
1,923 citations
Authors
Showing all 4184 results
Name | H-index | Papers | Citations |
---|---|---|---|
David J. Brooks | 152 | 1056 | 94335 |
Ryoji Noyori | 105 | 627 | 47578 |
Michael B. Yaffe | 102 | 379 | 41663 |
Magnus Karlsson | 91 | 1226 | 38208 |
Bengt Långström | 83 | 700 | 30513 |
Jonathon Pines | 81 | 138 | 22961 |
Ian D. Wilson | 80 | 594 | 33379 |
James R. MacFall | 73 | 237 | 15358 |
Richard G. Frank | 71 | 399 | 22928 |
Kevin M. Brindle | 70 | 296 | 19633 |
Scott B. Reeder | 67 | 368 | 18258 |
John H. Reif | 67 | 427 | 21692 |
Guanghui Ma | 66 | 497 | 17108 |
Joshua Fierer | 59 | 190 | 12760 |
W. K. Peterson | 58 | 261 | 12538 |