P
Pamela N. Munster
Researcher at University of California, San Francisco
Publications - 311
Citations - 16254
Pamela N. Munster is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 59, co-authored 286 publications receiving 13471 citations. Previous affiliations of Pamela N. Munster include Memorial Sloan Kettering Cancer Center & University of San Francisco.
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Journal ArticleDOI
Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate
Sarah J. Nelson,John Kurhanewicz,Daniel B. Vigneron,Peder E. Z. Larson,Andrea L. Harzstark,Marcus Ferrone,Mark Van Criekinge,Jose W. Chang,Robert Bok,Ilwoo Park,Galen D. Reed,Lucas Carvajal,Eric J. Small,Pamela N. Munster,Vivian Weinberg,Jan Henrik Ardenkjær-Larsen,Albert P. Chen,Ralph E. Hurd,Liv-Ingrid Odegardstuen,Fraser Robb,James Tropp,Jonathan Alan Murray +21 more
TL;DR: This first-in-man imaging study evaluated the safety and feasibility of hyperpolarized [1-13C]pyruvate as an agent for noninvasively characterizing alterations in tumor metabolism for patients with prostate cancer and showed elevated levels of lactate, alanine, and bicarbonate in regions of biopsy-proven cancer.
Journal ArticleDOI
KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors.
David S. Hong,Marwan Fakih,John H. Strickler,Jayesh Desai,G. Durm,Geoffrey I. Shapiro,Gerald S. Falchook,Timothy J. Price,Adrian G. Sacher,Crystal S. Denlinger,Yung-Jue Bang,Grace K. Dy,John C. Krauss,Yasutoshi Kuboki,James Kuo,Andrew L. Coveler,Keunchil Park,Tae Won Kim,Fabrice Barlesi,Pamela N. Munster,Suresh S. Ramalingam,Timothy F. Burns,Funda Meric-Bernstam,H. Henary,J. Ngang,Gataree Ngarmchamnanrith,J. Kim,Brett E. Houk,Jude Canon,J. Russell Lipford,Gregory Friberg,Piro Lito,Ramaswamy Govindan,Bob T. Li +33 more
TL;DR: Sotorasib showed encouraging anticancer activity in patients with heavily pretreated advanced solid tumors harboring the KRAS p.G12C mutation and responded to pharmacokinetics and objective response according to Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1.
Journal ArticleDOI
Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma.
Adil Daud,Ronald C. DeConti,S. Andrews,P. Urbas,Adam I. Riker,Vernon K. Sondak,Pamela N. Munster,Daniel M. Sullivan,Kenneth E. Ugen,Jane L. Messina,Richard Heller +10 more
TL;DR: This report describes the first human trial, to the authors' knowledge, of gene transfer utilizing in vivo DNA electroporation and indicated this modality to be safe, effective, reproducible, and titratable.
Journal Article
17-Allylamino-17-demethoxygeldanamycin Induces the Degradation of Androgen Receptor and HER-2/neu and Inhibits the Growth of Prostate Cancer Xenografts
David B. Solit,Fuzhong F. Zheng,Maria Drobnjak,Pamela N. Munster,Brian Higgins,David Verbel,Glenn Heller,William P. Tong,Carlos Cordon-Cardo,David B. Agus,Howard I. Scher,Neal Rosen +11 more
TL;DR: It is demonstrated that, at a tolerable dose, inhibition of Hsp90 function by 17-AAG results in a marked reduction in HER2, AR, and Akt expression and inhibition of prostate tumor growth in mice, suggesting that this drug may represent a new strategy for the treatment of prostate cancer.
Journal Article
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells.
Pamela N. Munster,Tiffany A. Troso-Sandoval,Neal Rosen,Richard A. Rifkind,Paul A. Marks,Victoria M. Richon +5 more
TL;DR: It is proposed that SAHA has profound antiproliferative activity by causing these cells to undergo cell cycle arrest and differentiation that is dependent on the presence of SAHA.