抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Metamaterials, artificial electromagnetic media that are structured on the subwavelength scale, were initially suggested for the negative-index 'superlens'. Later metamaterials became a paradigm for engineering electromagnetic space and controlling propagation of waves: the field of transformation optics was born. The research agenda is now shifting towards achieving tunable, switchable, nonlinear and sensing functionalities. It is therefore timely to discuss the emerging field of metadevices where we define the devices as having unique and useful functionalities that are realized by structuring of functional matter on the subwavelength scale. In this Review we summarize research on photonic, terahertz and microwave electromagnetic metamaterials and metadevices with functionalities attained through the exploitation of phase-change media, semiconductors, graphene, carbon nanotubes and liquid crystals. The Review also encompasses microelectromechanical metadevices, metadevices engaging the nonlinear and quantum response of superconductors, electrostatic and optomechanical forces and nonlinear metadevices incorporating lumped nonlinear components.

/pdf/from-metamaterials-to-metadevices-4vgaose515.pdf

From metamaterials to metadevices.

Metamaterials are composed of periodic subwavelength metal/dielectric structures that resonantly couple to the electric and/or magnetic components of the incident electromagnetic fields, exhibiting properties that are not found in nature. This class of micro- and nano-structured artificial media have attracted great interest during the past 15 years and yielded ground-breaking electromagnetic and photonic phenomena. However, the high losses and strong dispersion associated with the resonant responses and the use of metallic structures, as well as the difficulty in fabricating the micro- and nanoscale 3D structures, have hindered practical applications of metamaterials. Planar metamaterials with subwavelength thickness, or metasurfaces, consisting of single-layer or few-layer stacks of planar structures, can be readily fabricated using lithography and nanoprinting methods, and the ultrathin thickness in the wave propagation direction can greatly suppress the undesirable losses. Metasurfaces enable a spatially varying optical response (e.g. scattering amplitude, phase, and polarization), mold optical wavefronts into shapes that can be designed at will, and facilitate the integration of functional materials to accomplish active control and greatly enhanced nonlinear response. This paper reviews recent progress in the physics of metasurfaces operating at wavelengths ranging from microwave to visible. We provide an overview of key metasurface concepts such as anomalous reflection and refraction, and introduce metasurfaces based on the Pancharatnam-Berry phase and Huygens' metasurfaces, as well as their use in wavefront shaping and beam forming applications, followed by a discussion of polarization conversion in few-layer metasurfaces and their related properties. An overview of dielectric metasurfaces reveals their ability to realize unique functionalities coupled with Mie resonances and their low ohmic losses. We also describe metasurfaces for wave guidance and radiation control, as well as active and nonlinear metasurfaces. Finally, we conclude by providing our opinions of opportunities and challenges in this rapidly developing research field.

A review of metasurfaces: physics and applications.

Metamaterials are composed of periodic subwavelength metal/dielectric structures that resonantly couple to the electric and/or magnetic components of the incident electromagnetic fields, exhibiting properties that are not found in nature. Planar metamaterials with subwavelength thickness, or metasurfaces, consisting of single-layer or few-layer stacks of planar structures, can be readily fabricated using lithography and nanoprinting methods, and the ultrathin thickness in the wave propagation direction can greatly suppress the undesirable losses. Metasurfaces enable a spatially varying optical response, mold optical wavefronts into shapes that can be designed at will, and facilitate the integration of functional materials to accomplish active control and greatly enhanced nonlinear response. This paper reviews recent progress in the physics of metasurfaces operating at wavelengths ranging from microwave to visible. We provide an overview of key metasurface concepts such as anomalous reflection and refraction, and introduce metasurfaces based on the Pancharatnam-Berry phase and Huygens' metasurfaces, as well as their use in wavefront shaping and beam forming applications, followed by a discussion of polarization conversion in few-layer metasurfaces and their related properties. An overview of dielectric metasurfaces reveals their ability to realize unique functionalities coupled with Mie resonances and their low ohmic losses. We also describe metasurfaces for wave guidance and radiation control, as well as active and nonlinear metasurfaces. Finally, we conclude by providing our opinions of opportunities and challenges in this rapidly developing research field.

A review of metasurfaces: physics and applications

Metasurfaces: From microwaves to visible

We demonstrate a low-profile holographic imaging system at millimeter wavelengths based on an aperture composed of frequency-diverse metasurfaces. Utilizing measurements of spatially-diverse field patterns, diffraction-limited images of human-sized subjects are reconstructed. The system is driven by a single microwave source swept over a band of frequencies (17.5–26.5 GHz) and switched between a collection of transmit and receive metasurface panels. High fidelity image reconstruction requires a precise model for each field pattern generated by the aperture, as well as the manner in which the field scatters from objects in the scene. This constraint makes scaling of computational imaging systems inherently challenging for electrically large, coherent apertures. To meet the demanding requirements, we introduce computational methods and calibration approaches that enable rapid and accurate imaging performance.

/pdf/large-metasurface-aperture-for-millimeter-wave-computational-u1eksy00cn.pdf

Large Metasurface Aperture for Millimeter Wave Computational Imaging at the Human-Scale.

The radiative processes associated with fluorophores and other radiating systems can be profoundly modified by their interaction with nanoplasmonic structures. Extreme electromagnetic environments can be created in plasmonic nanostructures or nanocavities, such as within the nanoscale gap region between two plasmonic nanoparticles, where the illuminating optical fields and the density of radiating modes are dramatically enhanced relative to vacuum. Unraveling the various mechanisms present in such coupled systems, and their impact on spontaneous emission and other radiative phenomena, however, requires a suitably reliable and precise means of tuning the plasmon resonance of the nanostructure while simultaneously preserving the electromagnetic characteristics of the enhancement region. Here, we achieve this control using a plasmonic platform consisting of colloidally synthesized nanocubes electromagnetically coupled to a metallic film. Each nanocube resembles a nanoscale patch antenna (or nanopatch) whose ...

/pdf/control-of-radiative-processes-using-tunable-plasmonic-4gmxzdi6op.pdf

Control of radiative processes using tunable plasmonic nanopatch antennas.

Recently, a frequency-diverse, metamaterial-based aperture has been introduced in the context of microwave and millimeter wave imaging. The generic form of the aperture is that of a parallel plate waveguide, in which complementary metamaterial elements patterned into the upper plate couple energy from the waveguide mode to the scene. To reliably predict the imaging performance of such an aperture prior to fabrication and experiments, it is necessary to have an accurate forward model that predicts radiation from the aperture, a model for scattering from an arbitrary target in the scene, and a set of image reconstruction approaches that allow scene estimation from an arbitrary set of measurements. Here, we introduce a forward model in which the metamaterial elements are approximated as polarizable magnetic dipoles, excited by the fields propagating within the waveguide. The dipoles used in the model can have arbitrarily assigned polarizability characteristics. Alternatively, fields measured from actual metamaterial samples can be decomposed into a set of effective dipole radiators, allowing the performance of actual samples to be quantitatively modeled and compared with simulated apertures. To confirm the validity of our model, we simulate measurements and scene reconstructions with a virtual multiaperture imaging system operating in the K-band spectrum (18-26.5 GHz) and compare its performance with an experimental system.

Comprehensive simulation platform for a metamaterial imaging system.

Nonlinear metamaterials have been predicted to support new and exciting domains in the manipulation of light, including novel phase-matching schemes for wave mixing. Most notable is the so-called nonlinear-optical mirror, in which a nonlinear negative-index medium emits the generated frequency towards the source of the pump. In this Letter, we experimentally demonstrate the nonlinear-optical mirror effect in a bulk negative-index nonlinear metamaterial, along with two other novel phase-matching configurations, utilizing periodic poling to switch between the three phase-matching domains.

https://physics.aps.org/featured-article-pdf/10.1103/PhysRevLett.107.063902

Controlling the second harmonic in a phase-matched negative-index metamaterial.

The resolution of a frequency diverse compressive metamaterial aperture imager is investigated. The aperture consists of a parallel plate waveguide, in which an array of complementary, resonant metamaterial elements is patterned into one of the plates. Microwaves injected into the waveguide leak out through the resonant metamaterial elements, forming a spatially diverse waveform at the scene. As the frequency is scanned, the waveforms change, such that scene information can be encoded onto a set of frequency measurements. The compressive nature of the metamaterial imager enables image reconstruction from a significantly reduced number of measurements. We characterize the resolution of this complex aperture by studying the simulated point spread function (PSF) computed using different image reconstruction techniques. We compare the imaging performance of the system with that expected from synthetic aperture radar (SAR) limits.

/pdf/resolution-of-the-frequency-diverse-metamaterial-aperture-10os6bc8nj.pdf

Alec Rose

Papers

Large Metasurface Aperture for Millimeter Wave Computational Imaging at the Human-Scale.

Control of radiative processes using tunable plasmonic nanopatch antennas.

Comprehensive simulation platform for a metamaterial imaging system.

Controlling the second harmonic in a phase-matched negative-index metamaterial.

Resolution of the Frequency Diverse Metamaterial Aperture Imager