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Alejandro Soto-Gutierrez
Researcher at University of Pittsburgh
Publications - 111
Citations - 6779
Alejandro Soto-Gutierrez is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Transplantation & Stem cell. The author has an hindex of 36, co-authored 102 publications receiving 5981 citations. Previous affiliations of Alejandro Soto-Gutierrez include Shriners Hospitals for Children & Boston Children's Hospital.
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Journal ArticleDOI
Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix
Basak E. Uygun,Alejandro Soto-Gutierrez,Alejandro Soto-Gutierrez,Hiroshi Yagi,Hiroshi Yagi,Maria Louisa Izamis,Maria Angela Guzzardi,Maria Angela Guzzardi,Carley Shulman,Jack M. Milwid,Naoya Kobayashi,Arno W. Tilles,Francois Berthiaume,Francois Berthiaume,Martin Hertl,Yaakov Nahmias,Yaakov Nahmias,Martin L. Yarmush,Martin L. Yarmush,Korkut Uygun +19 more
TL;DR: A novel approach to generate transplantable liver grafts using decellularized liver matrix that preserves the structural and functional characteristics of the native microvascular network, allowing efficient recellularization of the liver matrix with adult hepatocytes and subsequent perfusion for in vitro culture.
Journal ArticleDOI
Mesenchymal stem cells: Mechanisms of immunomodulation and homing.
Hiroshi Yagi,Alejandro Soto-Gutierrez,Biju Parekkadan,Yuko Kitagawa,Ronald G. Tompkins,Naoya Kobayashi,Martin L. Yarmush,Martin L. Yarmush +7 more
TL;DR: The known mechanisms of immunomodulation and homing of MSCs are described and contextualized to understand a reported side effect of M SC therapy, cancer development.
Journal ArticleDOI
Differentiation and Transplantation of Human Embryonic Stem Cell-Derived Hepatocytes
Hesham Basma,Alejandro Soto-Gutierrez,Govardhana Rao Yannam,Liping Liu,Ryotaro Ito,Toshiyuki Yamamoto,Ewa Ellis,Steven D. Carson,Shintaro Sato,Yong Chen,David Muirhead,Nalu Navarro-Alvarez,Ronald J. Wong,Jayanta Roy-Chowdhury,Jeffrey L. Platt,David F. Mercer,John D. Miller,Stephen C. Strom,Naoya Kobayashi,Ira J. Fox +19 more
TL;DR: Embryonic stem cell-derived hepatocytes expressed liver-specific genes, but not genes representing other lineages, secreted functional human liver- specific proteins similar to those of primary human hepatocytes, and showed human hepatocyte cytochrome P450 metabolic activity.
Journal ArticleDOI
A Whole-Organ Regenerative Medicine Approach for Liver Replacement
Alejandro Soto-Gutierrez,Li Zhang,Christopher J. Medberry,Ken Fukumitsu,Denver M. Faulk,Hongbin Jiang,Janet E. Reing,Roberto Gramignoli,Junji Komori,Mark A. Ross,Masaki Nagaya,Eric Lagasse,Donna B. Stolz,Stephen C. Strom,Ira J. Fox,Stephen F. Badylak +15 more
TL;DR: W Whole-organ liver decellularization is possible with maintenance of structure and composition suitable to support functional hepatocytes and three different cell reseeding strategies to engineer functional liver tissue are investigated.
Journal ArticleDOI
Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell-derived hepatocytes
Alejandro Soto-Gutierrez,Naoya Kobayashi,Jorge David Rivas-Carrillo,Nalu Navarro-Alvarez,Debaio Zhao,Teru Okitsu,Hirofumi Noguchi,Hesham Basma,Yashuhiko Tabata,Yong Chen,Kimiaki Tanaka,Michiki Narushima,Atsushi Miki,Tadayoshi Ueda,Hee-Sook Jun,Hee-Sook Jun,Ji-Won Yoon,Jane S. Lebkowski,Noriaki Tanaka,Ira J. Fox +19 more
TL;DR: Mouse embryonic stem cells are differentiated into hepatocytes by coculture with a combination of human liver nonparenchymal cell lines and fibroblast growth factor-2, human activin-A and hepatocyte growth factor to generate an alternative source of cells for BAL support.