Francois Berthiaume

TL;DR: A novel approach to generate transplantable liver grafts using decellularized liver matrix that preserves the structural and functional characteristics of the native microvascular network, allowing efficient recellularization of the liver matrix with adult hepatocytes and subsequent perfusion for in vitro culture.

TL;DR: The physiology of monocytes and macrophages in acute wound healing and the different phenotypes described in the literature for both in vitro and in vivo models are discussed.

TL;DR: It is reported that the administration of MSC-derived molecules in two clinically relevant forms-intravenous bolus of conditioned medium or extracorporeal perfusion with a bioreactor containing MSCs-can provide a significant survival benefit in rats undergoing FHF and support the role of chemokines and altered leukocyte migration as a novel therapeutic modality for FHF.

TL;DR: This review highlights the modest beginnings of tissue engineering and regenerative medicine and describes three application examples that are in various stages of development, ranging from relatively mature to ongoing proof-of-concept (cartilage) to early stage (liver).

TL;DR: These data provide the first clear evidence that MSC‐CM therapy provides trophic support to the injured liver by inhibiting hepatocellular death and stimulating regeneration, potentially creating new avenues for the treatment of FHF.