A
Alena Skálová
Researcher at Charles University in Prague
Publications - 162
Citations - 5879
Alena Skálová is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Salivary gland & Adenocarcinoma. The author has an hindex of 37, co-authored 145 publications receiving 4541 citations.
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Journal ArticleDOI
Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.
Alena Skálová,Tomas Vanecek,Radek Sima,Jan Laco,Ilan Weinreb,Bayardo Perez-Ordonez,Ivo Stárek,Marie Geierova,Roderrick H W Simpson,Fabricio Passador-Santos,Ales Ryska,Ilmo Leivo,Zdenek Kinkor,Michal Michal +13 more
TL;DR: The results strongly support the concept that MASC and AciCC are different entities.
Journal ArticleDOI
Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entity.
TL;DR: The finding of duct involvement, proven with an incomplete p63-positive basal layer surrounding a minority of tumor cell nests and cysts, raised the possibility of a ductal epithelial origin for MASC, and reinforce MASC as a unique low-grade salivary gland tumor entity with morphologic overlap with AciCC, MEC, and cystadenocarcinoma.
Journal ArticleDOI
Mammary Analogue Secretory Carcinoma of Salivary Glands With High-grade Transformation: Report of 3 Cases With the ETV6-NTRK3 Gene Fusion and Analysis of TP53, β-Catenin, EGFR, and CCND1 Genes
Alena Skálová,Tomas Vanecek,Hanna Majewska,Jan Laco,Petr Grossmann,Roderick H.W. Simpson,Lukas Hauer,P. Andrle,L. Hosticka,Jindrich Branžovský,Michal Michal +10 more
TL;DR: Recognizing HG-transformed MASC and testing for ETV 6 rearrangement may be of potential value in patient treatment, because the presence of the ETV6-NTRK3 translocation may represent a therapeutic target in MASC.
Journal ArticleDOI
Expression of HER-2/neu gene and protein in salivary duct carcinomas of parotid gland as revealed by fluorescence in-situ hybridization and immunohistochemistry.
Alena Skálová,Ivo Stárek,Tomas Vanecek,V. Kučerová,Lukáš Plank,Szépe P,S Di Palma,Ilmo Leivo +7 more
TL;DR: In immunohistochemistry, over-expression of HER-2/neu protein was identified as distinct membrane staining in most carcinoma cells in all salivary duct carcinoma cases, while only four cases revealed an amplification of Her-2 /neu gene by means of FISH analysis.
Journal ArticleDOI
Mammary Analogue Secretory Carcinoma of Salivary Glands: Molecular Analysis of 25 ETV6 Gene Rearranged Tumors With Lack of Detection of Classical ETV6-NTRK3 Fusion Transcript by Standard RT-PCR: Report of 4 Cases Harboring ETV6-X Gene Fusion.
Alena Skálová,Tomas Vanecek,Roderick H.W. Simpson,Jan Laco,Hanna Majewska,Martina Baneckova,Petr Steiner,Michal Michal +7 more
TL;DR: Numbers were small, correlating the clinico-pathologic features of the 4 ETV6-X fusion tumors and 5 MASC cases with atypical fusion transcripts raises the possibility of that they may behave more aggressively.