J
Jan Laco
Researcher at Charles University in Prague
Publications - 158
Citations - 5052
Jan Laco is an academic researcher from Charles University in Prague. The author has contributed to research in topics: DNA methylation & Medicine. The author has an hindex of 29, co-authored 138 publications receiving 3957 citations. Previous affiliations of Jan Laco include Universidad Nacional de Asunción.
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Journal ArticleDOI
Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.
Alena Skálová,Tomas Vanecek,Radek Sima,Jan Laco,Ilan Weinreb,Bayardo Perez-Ordonez,Ivo Stárek,Marie Geierova,Roderrick H W Simpson,Fabricio Passador-Santos,Ales Ryska,Ilmo Leivo,Zdenek Kinkor,Michal Michal +13 more
TL;DR: The results strongly support the concept that MASC and AciCC are different entities.
Journal ArticleDOI
HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients
Xavier Castellsagué,Laia Alemany,Miquel Quer,Gordana Halec,Beatriz Quirós,Sara Tous,Omar Clavero,Llucia Alos,Thorsten Biegner,Tomasz Szafarowski,Maria Alejo,Dana Holzinger,Enrique Cadena,Edith Claros,Gillian Hall,Jan Laco,Mario Poljak,Maria Benevolo,Elena Kasamatsu,Hisham Mehanna,Cathy Ndiaye,Núria Guimerà,Belen Lloveras,Xavier León,Juan C. Ruiz-Cabezas,Isabel Alvarado-Cabrero,Chang Suk Kang,Jin-Kyoung Oh,Marcial Garcia-Rojo,Ermina Iljazovic,Oluseyi F. Ajayi,Flora Duarte,Ashrafun Nessa,Leopoldo Tinoco,Marco A. Duran-Padilla,Edyta C. Pirog,Halina Viarheichyk,Hesler Morales,Valérie Costes,Ana Félix,Maria Julieta V Germar,Marisa Mena,Arzu Ruacan,Asha Jain,Ravi Mehrotra,Marc T. Goodman,Luis Estuardo Lombardi,Annabelle Ferrera,Sani Malami,Estela I. Albanesi,Pablo Dabed,Carla Molina,Rubén López-Revilla,Václav Mandys,Manuel E. González,Julio Velasco,Ignacio G. Bravo,Wim Quint,Michael Pawlita,Nubia Muñoz,Silvia de Sanjosé,F. Xavier Bosch +61 more
TL;DR: This large international study to estimate fractions of head and neck cancers attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation confirms the important role ofHPVs in oropharyngeal cancer and drastically downplays the previously reported involvement of HPVs in the other HNCs.
Journal ArticleDOI
Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva
Silvia de Sanjosé,Laia Alemany,Jaume Ordi,Sara Tous,Maria Alejo,Susan M. Bigby,Elmar A. Joura,Paula Maldonado,Jan Laco,Ignacio G. Bravo,August Vidal,Núria Guimerà,Paul Cross,Gerard Wain,Karl Ulrich Petry,Luciano Mariani,Christine Bergeron,Václav Mandys,Adela Rosa Sica,Ana Félix,Alp Usubutun,Muhieddine Seoud,Gustavo Hernández-Suárez,Andrzej Nowakowski,G. Wilson,Véronique Dalstein,Monika Hampl,Elena Kasamatsu,Luis Estuardo Lombardi,Leopoldo Tinoco,Isabel Alvarado-Cabrero,Myriam Perrotta,Neerja Bhatla,Theodoros Agorastos,Charles F. Lynch,Marc T. Goodman,Hai Rim Shin,Halina Viarheichyk,Robert Jach,M. O.L.Eugenia Cruz,Julio Velasco,Carla Molina,Jacob Bornstein,Annabelle Ferrera,Efren J. Domingo,Cheng Yang Chou,Adekunbiola Aina Fehintola Banjo,Xavier Castellsagué,Michael Pawlita,Belen Lloveras,Wim Quint,Nubia Muñoz,F. Xavier Bosch +52 more
TL;DR: Combined data from HPV-DNA and p16(INK4a) testing are likely to represent a closer estimate of the real fraction of IVC induced by HPV, indicating that HPV contribution in invasive vulvar cancer has probably been overestimated.
Journal ArticleDOI
Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide.
Laia Alemany,Maëlle Saunier,Isabel Alvarado-Cabrero,Beatriz Quirós,Jorge Salmerón,Hai-Rim Shin,Edyta C. Pirog,Núria Guimerà,Gustavo Hernández-Suárez,Ana Félix,Omar Clavero,Belen Lloveras,Elena Kasamatsu,Marc T. Goodman,Marc T. Goodman,Brenda Y. Hernandez,Jan Laco,Leopoldo Tinoco,D.T. Geraets,Charles F. Lynch,Václav Mandys,Mario Poljak,Robert Jach,Josep Verge,Christine Clavel,Cathy Ndiaye,Joellen Klaustermeier,Antonio L. Cubilla,Xavier Castellsagué,Ignacio G. Bravo,Michael Pawlita,William G. Quint,Nubia Muñoz,Francesc Bosch,Silvia de Sanjosé +34 more
TL;DR: In view of the results of HPV DNA and high proportion of p16INK4a overexpression, infection by HPV is most likely to be a necessary cause for anal cancers in both men and women.
Journal ArticleDOI
Role of Human Papillomavirus in Penile Carcinomas Worldwide
Laia Alemany,Antonio L. Cubilla,Gordana Halec,Elena Kasamatsu,Beatriz Quirós,Emili Masferrer,Sara Tous,Belen Lloveras,Gustavo Hernández-Suárez,Ray Lonsdale,Leopoldo Tinoco,Maria Alejo,Isabel Alvarado-Cabrero,Jan Laco,Núria Guimerà,Enrique Poblet,Luis Estuardo Lombardi,Christine Bergeron,Omar Clavero,Hai-Rim Shin,Annabelle Ferrera,Ana Félix,Julieta Germar,Václav Mandys,Christine Clavel,Maria Tzardi,Luis E. Pons,Vincent Wain,Eugenia Cruz,Carla Molina,Jose D. Mota,Robert Jach,Julio Velasco,Carla Carrilho,Rubén López-Revilla,Marc T. Goodman,Marc T. Goodman,Wim Quint,Xavier Castellsagué,Ignacio G. Bravo,Michael Pawlita,Nubia Muñoz,F. Xavier Bosch,Silvia de Sanjosé +43 more
TL;DR: About a third to a fourth of penile cancers were related to HPV when considering HPV DNA detection alone or adding an HPV activity marker, respectively, and the observed HPV type distribution reinforces the potential benefit of current and new HPV vaccines in the reduction of HPV-related penile neoplastic lesions.