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Alesha B. Castillo
Researcher at New York University
Publications - 54
Citations - 3176
Alesha B. Castillo is an academic researcher from New York University. The author has contributed to research in topics: Mechanotransduction & Osteoblast. The author has an hindex of 24, co-authored 52 publications receiving 2805 citations. Previous affiliations of Alesha B. Castillo include Veterans Health Administration & University of California, Davis.
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Journal ArticleDOI
Biomechanical and molecular regulation of bone remodeling
TL;DR: The molecular mechanisms by which bone adapts to loading and repairs damage are starting to become clear, and have implications for bone health, disease, and the feasibility of living in weightless environments (e.g., spaceflight).
Journal ArticleDOI
Exercise when young provides lifelong benefits to bone structure and strength.
Stuart J. Warden,Stuart J. Warden,Robyn K. Fuchs,Alesha B. Castillo,Ian Nelson,Charles H. Turner,Charles H. Turner +6 more
TL;DR: Short‐term exercise in growing rodents provided lifelong benefits to bone structure, strength, and fatigue resistance, and the old exercise adage of “use it or lose it” may not be entirely applicable to the skeleton.
Journal ArticleDOI
Osteocyte mechanobiology and pericellular mechanics.
TL;DR: This review outlines the process in bone by tracing mechanical effects from the organ level to the cellular and molecular levels and by integrating the biological response from molecule to organ.
Journal ArticleDOI
The epigenetic mechanism of mechanically induced osteogenic differentiation.
Emily J. Arnsdorf,Padmaja Tummala,Alesha B. Castillo,Alesha B. Castillo,Fan Zhang,Christopher R. Jacobs +5 more
TL;DR: It is demonstrated that mechanical stimulation alters their epigenetic state by reducing DNA methylation and show an associated increase in expression, the first demonstration of a mechanism by which the mechanical micro-environment is able to induce epigenetic changes that control osteogenic cell fate, and that can be passed to daughter cells.
Journal ArticleDOI
Biological Effects of Short-Term or Prolonged Administration of 9-[2-(Phosphonomethoxy)Propyl]Adenine (Tenofovir) to Newborn and Infant Rhesus Macaques
Koen K. A. Van Rompay,Laurie L. Brignolo,Dennis J. Meyer,Christopher Jerome,Ross P. Tarara,Abigail Spinner,Marta Hamilton,Linda Hirst,David R. Bennett,Don R. Canfield,Trish G. Dearman,Wilhelm Von Morgenland,Phil C. Allen,Celia R. Valverde,Alesha B. Castillo,R. Bruce Martin,Valerie F. Samii,Ray Bendele,John Desjardins,Marta L. Marthas,Niels C Pedersen,Norbert Bischofberger +21 more
TL;DR: It is suggested that chronic daily administration of a high dose of PMPA results in adverse effects on kidney and bone, while short-term administration of relatively high doses and prolonged low-dose administration are safe.