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Alessandra Iurlo

Researcher at Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Publications -  318
Citations -  5258

Alessandra Iurlo is an academic researcher from Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. The author has contributed to research in topics: Medicine & Myeloid leukemia. The author has an hindex of 31, co-authored 255 publications receiving 3769 citations. Previous affiliations of Alessandra Iurlo include University of Milan.

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Congenital dyserythropoietic anemia type II (CDAII) is caused by mutations in the SEC23B gene.

TL;DR: Abnormalities in this gene are likely to disturb endoplasmic reticulum (ER)‐to‐Golgi trafficking, affecting different glycosylation pathways and ultimately accounting for the cellular phenotype observed in CDAII.
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The European Consensus on grading of bone marrow fibrosis allows a better prognostication of patients with primary myelofibrosis.

TL;DR: Analysis of the overall survival curves documented that patients classified as having the most favourable rate with both prognostic scores survive longer than those with only one favourable score, while better prognostication can be achieved in primary myelofibrosis patients when both systems are used together.