Showing papers in "Modern Pathology in 2012"

TL;DR: This statement proposes a terminology scheme for the diagnosis of IgG4-related disease that is based primarily on the morphological appearance on biopsy, and advocates the use of strict criteria for accepting newly proposed entities or sites as components of the IgG 4- related disease spectrum.

TL;DR: This paper provides the most up-to-date practical guidance on HER2 testing and scoring in patients with gastric and gastro–esophageal junction cancer, as agreed by a panel of expert pathologists with extensive experience of Her2 testing particularly reflecting the European Medicines Agency-approved indication.

TL;DR: Patients with resected primary solitary fibrous tumor were identified and the most common sites of occurrence were abdomen and pleura; these tumors were larger than those occurring in the extremities, head and neck or trunk, but did not demonstrate significant outcome differences.

TL;DR: In this article, the p40 antibody was compared to p63 in a series of 470 tumors from the archives of Memorial Sloan-Kettering Cancer Center and The Johns Hopkins Hospital, which included lung squamous cell carcinomas, adenocarcinomas, and large cell lymphomas.

TL;DR: Heterogeneity of Her2 gene amplification is present in a subset of HER2-amplified breast cancers, especially in cases with low-grade HER2 amplification and equivocal HER2 expression, indicating a need for HER2 testing on more representative, larger tumor samples for accurate assessment of her2 status in such cases.

TL;DR: The morphology of tumor budding and its relationship to other potentially important features of the invasive front are described and the challenges posed by a lack of data to allow standardization with respect to the qualitative and quantitative criteria used to define budding are highlighted.

TL;DR: A histologic, molecular, and immunophenotypic analysis of patients with sporadic early-onset (≤40 years of age) colorectal carcinoma seen at the authors' institution and compared these tumors to a cohort of consecutively resected coloreCTal carcinomas seen in patients in patients >40 Years of age demonstrates that colorec carcinoma is not infrequently diagnosed in patients with chronic inflammatory conditions.

TL;DR: It is concluded that MYC/BCL2 lymphomas are clinically aggressive, irrespective of their morphological appearance, with a germinal center B-cell immunophenotype.

TL;DR: Recent developments involving the specific molecular mechanisms and markers that have been associated with primary and acquired resistance to EGFR-targeted therapy in lung adenocarcinomas are summarized.

TL;DR: The presence of MYC amplification represents an important additional diagnostic tool in the distinction of postradiation cutaneous angiosarcomas from atypical vascular lesions after radiotherapy.

TL;DR: This review will address some of the diagnostic problems that occur in the minority of cases of small cell lung cancer and outline practical ways to address them.

TL;DR: In pulmonary adenocarcinomas with classic morphology, which comprise the majority of cases, there is good reproducibility in identifying a predominant pattern and fair Reproducibility distinguishing invasive from in-situ (wholly lepidic) patterns.

TL;DR: DOG1 staining is a marker of salivary acinar and to a lesser extent intercalated duct differentiation and may also be a markers of a ‘transformed’ myoepithelial phenotype in a subset of biphasic Salivary gland malignancies.

TL;DR: The results suggest that loss of ARID1A protein expression occurs as a very early event in ovarian clear-cell carcinoma development, similar to the pattern of PIK3CA mutation recently reported by the group, and frequently coexists (not mutually exclusive) with Pik3CA mutations.

TL;DR: Preliminary data indicate potential strong associations between morphology and genotype in high-grade serous carcinomas in BRCA1-associated and unassociated cases.

TL;DR: It is demonstrated that loss of ARID1A in ovarian clear cell carcinoma is a negative prognostic factor in patients treated with platinum-based chemotherapy.

TL;DR: It is shown that this lymphoma type is a neoplasm with prominent classical and alternative nuclear factor-kB pathway activation in neoplastic cells, and alternative therapies, based on the tumor biology, need to be tested in patients with EBV-positive diffuse large B-cell lymphoma of the elderly.

TL;DR: The observation that ATRX and DAXX defects and the alternative lengthening of telomeres phenotype occurred only in pancreatic neuroendocrine tumors measuring ≥3 cm and their lymph node metastases suggests that these changes are late events in pancreato- Neuroendocrine tumor development.

TL;DR: The high frequency and specificity of P. acnes, detected by PAB antibody within Sarcoid granulomas, indicates that this indigenous bacterium might be the cause of granuloma formation in many sarcoid patients.

TL;DR: TP53 abnormalities and increased immune cell infiltrates are significantly more common in high-grade serous with germline and somatic mutations in BRCA1 or BRC a2, compared with tumors lacking BRCa abnormalities.

TL;DR: It is demonstrated that PTEN immunohistochemistry is able to identify the majority of cases with functional PTEN loss, and also detects additional cases with PTEN protein loss that would otherwise be undetected by gene sequencing.

TL;DR: This combined architectural/mitotic grade for lung adenocarcinoma is proposed as a practical method that can be applied in routine practice and stratifies patients with intermediate architectural grade into two prognostically distinct categories.

TL;DR: C cervical embryonal rhabdomyosarcoma may be another pathological manifestation in the spectrum of extrapulmonary pathology in the setting of pleuropulmonary blastoma, as 12 of the 14 patients remain disease-free following conservative surgery and chemotherapy.

TL;DR: Nuclear grading in epithelioid mesothelioma provides a simple, practical, and cost-effective prognostic tool that better stratifies clinical outcome and time to recurrence than currently available clinicopathologic factors.

TL;DR: It was found that combinations of two microRNAs could roughly separate neoplastic from non-neoplastic samples, and the microRNA profiles to subclassify ampullary adenocarcinomas into pancreatobiliary or intestinal type were identified.

TL;DR: In this article, the β-catenin gene (CTNNB1) mutations were detected in formalin-fixed paraffin-embedded tissues among spindle cell lesions, which can morphologically'mimic' desmoid tumors.

TL;DR: Findings indicate that epithelial–mesenchymal transition has a significant part in the morphological features of malignant mesothelioma, and that miR-205 down-regulation correlated significantly with both a mesenchyal phenotype and a more aggressive behavior.

TL;DR: The results show that CD133 expression is a predictor of poor clinical outcome for patients with ovarian cancer, supporting the proposed link between CD133 and cancer stem cells.

TL;DR: ALK rearrangement is rare in adult RCC but may be associated with distinct histological features and poor outcome, and another potential mechanism to elevate ALK expression, increased ALK gene copy number, was observed in 10% of adult CCRCC, where it is associated with a higher tumor grade and poorer outcome.

TL;DR: In conclusion, immunohistochemical ERG expression has no predictive value for prostate cancer recurrence or progression after radical prostatectomy and increasing ERG levels are associated with the upregulation of androgen receptor expression in clinical specimens.