A
Alessandra Mallei
Researcher at University of Milan
Publications - 35
Citations - 1657
Alessandra Mallei is an academic researcher from University of Milan. The author has contributed to research in topics: Hippocampus & Brain-derived neurotrophic factor. The author has an hindex of 19, co-authored 35 publications receiving 1419 citations. Previous affiliations of Alessandra Mallei include Cornell University & Karolinska Institutet.
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Acute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: the dampening action of antidepressants.
Laura Musazzi,Marco Milanese,Pasqualina Farisello,Simona Zappettini,Daniela Tardito,V.S. Barbiero,Tiziana Bonifacino,Alessandra Mallei,Pietro Baldelli,Giorgio Racagni,Maurizio Raiteri,Fabio Benfenati,Giambattista Bonanno,Maurizio Popoli +13 more
TL;DR: Patch-clamp recordings of pyramidal neurons in the prefrontal cortex revealed that stress increased glutamatergic transmission through both pre- and postsynaptic mechanisms, and that antidepressants may normalize it by reducing release probability.
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Social Isolation Stress Induces Anxious-Depressive-Like Behavior and Alterations of Neuroplasticity-Related Genes in Adult Male Mice.
TL;DR: Results suggest that anxious- and depressive-like behavior induced by social isolation stress correlates with reduction of several neuroplasticity-related genes in the hippocampus and prefrontal cortex of adult male mice.
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The Action of Antidepressants on the Glutamate System: Regulation of Glutamate Release and Glutamate Receptors
TL;DR: The development of NMDA receptor antagonists has opened new avenues for glutamatergic, rapid acting, antidepressants, while additional targets in the glutamate synapse await development of new compounds for better, faster antidepressant action.
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Physical Exercise and Antidepressants Enhance BDNF Targeting in Hippocampal CA3 Dendrites: Further Evidence of a Spatial Code for BDNF Splice Variants
Gabriele Baj,Valentina D'Alessandro,Laura Musazzi,Alessandra Mallei,Cesar Renato Sartori,Marina Sciancalepore,Daniela Tardito,Francesco Langone,Maurizio Popoli,Enrico Tongiorgi +9 more
TL;DR: The increased expression of BDNF in CA3 dendrites following antidepressants or exercise further supports the neurotrophin hypothesis of antidepressants action and confirms that the differential subcellular localization of BD NF mRNA splice variants provides a spatial code for a selective expression ofBDNF in specific sub cellular districts.
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Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression
Lucia Carboni,Serena Becchi,Chiara Piubelli,Alessandra Mallei,R. Giambelli,Maria Razzoli,Aleksander A. Mathé,Maurizio Popoli,Enrico Domenici +8 more
TL;DR: The objective of this work was to analyse the peripheral biomarker response in a gene-environment interaction model of depression by comparing Flinders Sensitive Line rats with the control Flinders Resistant Line to suggest biomarker studies in humans.