G
Giorgio Racagni
Researcher at University of Milan
Publications - 385
Citations - 18733
Giorgio Racagni is an academic researcher from University of Milan. The author has contributed to research in topics: Hippocampus & Neurotrophic factors. The author has an hindex of 70, co-authored 381 publications receiving 17600 citations. Previous affiliations of Giorgio Racagni include University of Pavia & Mario Negri Institute for Pharmacological Research.
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Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes
TL;DR: Data suggest that free radicals inhibit glutamate uptake primarily by long-lasting oxidation of protein sulfhydryl (SH) groups, and chemical modifiers of free SH groups, such as p-chloromercuribenzoate and N-ethylmaleimide, also induce uptake inhibition.
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Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus
TL;DR: It is proposed that adverse events taking place during brain maturation can modulate the expression of molecular players of cellular plasticity within selected brain regions, thus contributing to permanent alterations in brain function, which might ultimately lead to an increased vulnerability for psychiatric diseases.
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Treatment resistant depression: methodological overview and operational criteria.
Daniel Souery,Jay D. Amsterdam,C de Montigny,Yves Lecrubier,Stuart Montgomery,Olivier Lipp,Giorgio Racagni,Joseph Zohar,Julien Mendlewicz +8 more
TL;DR: The proposed criteria are intended for therapeutic trials in TRD, combining the evaluation of treatment efficiency and the validation of the concept of TRD itself, including major depression with poor response to two adequate trials of different classes of antidepressants.
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Peroxynitrite Inhibits Glutamate Transporter Subtypes
Davide Trotti,Daniela Rossi,Ola Gjesdal,Line M. Levy,Giorgio Racagni,Niels C. Danbolt,Andrea Volterra +6 more
TL;DR: The results suggest that the glutamate transporters contain conserved sites in their structures conferring vulnerability to ONOO and other oxidants.
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Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity
Francesca Calabrese,Andrea C. Rossetti,Giorgio Racagni,Peter Gass,Marco A. Riva,Raffaella Molteni +5 more
TL;DR: One of the most interesting hypotheses: the involvement of the neurotrophin brain-derived neurotrophic factor (BDNF), which represents one of the major mediators of neuroplasticity, is discussed.