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Alessandra S. Eustáquio
Researcher at University of Illinois at Chicago
Publications - 50
Citations - 2213
Alessandra S. Eustáquio is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Novobiocin & Burkholderia. The author has an hindex of 24, co-authored 46 publications receiving 1920 citations. Previous affiliations of Alessandra S. Eustáquio include University of California, San Diego & University of Montana.
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Journal ArticleDOI
Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse
Vinayak Agarwal,Zachary D. Miles,Jaclyn M. Winter,Alessandra S. Eustáquio,Abrahim El Gamal,Bradley S. Moore +5 more
TL;DR: The scope and mechanism of nature's halogenation and dehalogenation enzymatic strategies are detailed, gaps in understanding are highlighted, and where new advances in the field might arise in the near future are posits.
Journal ArticleDOI
Discovery and characterization of a marine bacterial SAM-dependent chlorinase
TL;DR: The genetic, biochemical and structural characterization of the chlorinase SalL is reported, which halogenates S-adenosyl-L-methionine with chloride to generate 5'-chloro-5'-deoxyadenosine and L-mETHionine in a rarely observed nucleophilic substitution strategy analogous to that of Streptomyces cattleya fluorinase.
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Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-l-methionine
Alessandra S. Eustáquio,Ryan P. McGlinchey,Yuan Liu,Christopher Hazzard,Laura L. Beer,Galina Florova,Mamoun M. Alhamadsheh,Anna Lechner,Andrew J. Kale,Yoshihisa Kobayashi,Kevin A. Reynolds,Bradley S. Moore +11 more
TL;DR: A pathway to chloroethylmalonyl-CoA as a polyketide synthase building block in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity is described.
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Engineering Fluorometabolite Production: Fluorinase Expression in Salinispora tropica Yields Fluorosalinosporamide
TL;DR: In this paper, the authors reported the induced production of fluorosalinosporamide by replacing the chlorinase gene salL from Salinispora tropica with the fluorinases gene flA.