A
Alessio Masi
Researcher at University of Florence
Publications - 53
Citations - 2200
Alessio Masi is an academic researcher from University of Florence. The author has contributed to research in topics: Excitatory postsynaptic potential & Membrane potential. The author has an hindex of 23, co-authored 46 publications receiving 1879 citations. Previous affiliations of Alessio Masi include Harvard University & University of Camerino.
Papers
More filters
Journal ArticleDOI
Targeting ion channels in cancer: a novel frontier in antineoplastic therapy
Annarosa Arcangeli,Olivia Crociani,Elena Lastraioli,Alessio Masi,Serena Pillozzi,Andrea Becchetti +5 more
TL;DR: It is proposed that a novel therapeutic tactic could be developed by unlocking ion channels from multiprotein membrane signaling complexes, which opens a new field for medicinal chemistry studies, which can avail of the many available tools.
Journal ArticleDOI
H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration.
TL;DR: It is shown that activity of the V-ATPase H+ pump is required for regeneration but not wound healing or tail development, and induction of H+ flux is sufficient to rescue axonal patterning and tail outgrowth in otherwise non-regenerative conditions.
Journal ArticleDOI
Induction of vertebrate regeneration by a transient sodium current.
TL;DR: A previously undetected competency window in which cells retain their intrinsic regenerative program is revealed, a novel endogenous role for NaV in regeneration is identified, and modulation of sodium transport represents an exciting new approach to organ repair.
Journal ArticleDOI
hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines
Alessio Masi,Andrea Becchetti,Rita Restano-Cassulini,Simone Polvani,Giovanna Hofmann,Annamaria Buccoliero,Milena Paglierani,B Pollo,Gianluigi Taddei,Pasquale Gallina,N. Di Lorenzo,Silvana Franceschetti,Enzo Wanke,Annarosa Arcangeli +13 more
TL;DR: HERG1 was found to be specifically overexpressed in high-grade astrocytomas, that is, glioblastoma multiforme (GBM), and evidence that, in GBM cell lines, hERG1 channel activity actively contributes to malignancy by promoting vascular endothelial growth factor secretion, thus stimulating the neoangiogenesis typical of high-grades gliomas.
Journal ArticleDOI
Optical mapping of neuronal activity during seizures in zebrafish.
Lapo Turrini,Chiara Fornetto,Giulia Marchetto,Marie Caroline Müllenbroich,Marie Caroline Müllenbroich,Natascia Tiso,Andrea Vettori,Francesco Resta,Alessio Masi,Guido Mannaioni,Francesco S. Pavone,Francesco S. Pavone,Francesco S. Pavone,Francesco Vanzi,Francesco Vanzi +14 more
TL;DR: This approach employed a transgenic line with pan-neuronal expression of the genetically-encoded calcium indicator GCaMP6s to measure neuronal activity in zebrafish larvae during seizures induced by pentylenetretrazole (PTZ), demonstrating the high sensitivity of this method to different levels of alteration.