A
Alex M. Abel
Researcher at Medical College of Wisconsin
Publications - 8
Citations - 753
Alex M. Abel is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Cohesin & Cell signaling. The author has an hindex of 6, co-authored 8 publications receiving 415 citations. Previous affiliations of Alex M. Abel include Gulf Coast Regional Blood Center.
Papers
More filters
Journal ArticleDOI
Natural Killer Cells: Development, Maturation, and Clinical Utilization
Alex M. Abel,Alex M. Abel,Chao Yang,Chao Yang,Monica S. Thakar,Monica S. Thakar,Subramaniam Malarkannan +6 more
TL;DR: Recent advances made in the understanding of how NK cells develop, mature, and their potential translational use in the clinic are summarized.
Journal ArticleDOI
IQGAP1: insights into the function of a molecular puppeteer.
Alex M. Abel,Kristina M. Schuldt,Kamalakannan Rajasekaran,David Hwang,Matthew J. Riese,Sridhar Rao,Monica S. Thakar,Subramaniam Malarkannan +7 more
TL;DR: How this pleiotropic scaffolin acts as a true molecular puppeteer is described, and the significance of future research regarding the role of IQGAP1 in immune cells is highlighted.
Journal ArticleDOI
The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9.
Joseph B. Fisher,Jonathan Peterson,Michael Reimer,Michael Reimer,Cary Stelloh,Kirthi Pulakanti,Zachary J. Gerbec,Alex M. Abel,Jennifer Strouse,Christopher Strouse,Maureen McNulty,Subramaniam Malarkannan,John D. Crispino,Samuel Milanovich,Sridhar Rao,Sridhar Rao +15 more
TL;DR: The studies identify a novel epigenetic mechanism underlying leukemogenesis in AML patients with cohesin mutations, which regulates PRC2 targeting to silence H Coxa7 and Hoxa9 and negatively regulate self-renewal.
Journal ArticleDOI
The Cohesin Subunit Rad21 Is a Negative Regulator of Hematopoietic Self-Renewal through Epigenetic Repression of HoxA7 and HoxA9
Joseph B. Fisher,Jonathan Peterson,Michael Reimer,Michael Reimer,Cary Stelloh,Kirthi Pulakanti,Zachary J. Gerbec,Zachary J. Gerbec,Alex M. Abel,Jennifer Strouse,Christopher Strouse,Maureen McNulty,Subramaniam Malarkannan,John D. Crispino,Samuel Milanovich,Sridhar Rao,Sridhar Rao +16 more
TL;DR: The studies identify a novel epigenetic mechanism underlying leukemogenesis and provide a possible therapeutic treatment for AML patients harboring cohesin mutations.
Journal ArticleDOI
IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells.
Alex M. Abel,Aradhana A. Tiwari,Zachary J. Gerbec,Jason R. Siebert,Chao Yang,Nathan J. Schloemer,Kate J. Dixon,Monica S. Thakar,Subramaniam Malarkannan +8 more
TL;DR: Results implicate IQGAP1 as an essential scaffold for NK cell homeostasis and function and provide novel mechanistic insights to the post-transcriptional regulation of inflammatory cytokine production.