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Alex P. Di Battista
Researcher at University of Toronto
Publications - 29
Citations - 754
Alex P. Di Battista is an academic researcher from University of Toronto. The author has contributed to research in topics: Concussion & Athletes. The author has an hindex of 13, co-authored 25 publications receiving 527 citations. Previous affiliations of Alex P. Di Battista include Defence Research and Development Canada & St. Michael's GAA, Sligo.
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Journal ArticleDOI
Inflammatory cytokine and chemokine profiles are associated with patient outcome and the hyperadrenergic state following acute brain injury
Alex P. Di Battista,Alex P. Di Battista,Shawn G. Rhind,Shawn G. Rhind,Michael G. Hutchison,Michael G. Hutchison,Syed Ahmed Hassan,Syed Ahmed Hassan,Maria Y. Shiu,Maria Y. Shiu,Kenji Inaba,Kenji Inaba,Jane Topolovec-Vranic,Antonio Capone Neto,Sandro Rizoli,Andrew J. Baker +15 more
TL;DR: The results provide further evidence that exaggerated SNS activation acutely after isolated TBI in humans may contribute to harmful peripheral inflammatory cytokine/chemokine dysregulation and are consistent with a potentially beneficial role for therapies aimed at modulating the inflammatory response and hyperadrenergic state acutely post-injury.
Journal ArticleDOI
Blood Biomarkers in Moderate-To-Severe Traumatic Brain Injury: Potential Utility of a Multi-Marker Approach in Characterizing Outcome
Alex P. Di Battista,Alex P. Di Battista,Alex P. Di Battista,John E. Buonora,John E. Buonora,Shawn G. Rhind,Shawn G. Rhind,Michael G. Hutchison,Andrew J. Baker,Sandro Rizoli,Ramon Diaz-Arrastia,Gregory P. Mueller +11 more
TL;DR: The prognostic performance of a recently developed multi-marker panel of circulating biomarkers that reflect specific pathogenic mechanisms including neuroinflammation, oxidative damage, and neuroregeneration, in moderate-to-severe TBI patients is characterized.
Journal ArticleDOI
Sympathoadrenal Activation is Associated with Acute Traumatic Coagulopathy and Endotheliopathy in Isolated Brain Injury.
Alex P. Di Battista,Sandro Rizoli,Brandon Lejnieks,Arimie Min,Maria Y. Shiu,Henry T. Peng,Andrew J. Baker,Michael G. Hutchison,Nathan W. Churchill,Kenji Inaba,Bartolomeu Nascimento,Airton Leonardo de Oliveira Manoel,Andrew Beckett,Shawn G. Rhind +13 more
TL;DR: Biomarker profiles in patients with an unfavorable outcome displayed procoagulation, hyperfibrinolysis, glycocalyx and endothelial damage, vasculature activation, and inflammation, suggesting biomarkers of coagulopathy and endotheliopathy are associated with poor outcome after TBI.
Journal ArticleDOI
Catecholamines as outcome markers in isolated traumatic brain injury: the COMA-TBI study.
Sandro Rizoli,Sandro Rizoli,Blessing N.R. Jaja,Alex P. Di Battista,Shawn G. Rhind,Antonio Capone Neto,Leodante da Costa,Kenji Inaba,Luis Teodoro da Luz,Bartolomeu Nascimento,Adic Perez,Adic Perez,Andrew J. Baker,Airton Leonardo de Oliveira Manoel +13 more
TL;DR: Elevated circulating catecholamines, especially Epi levels on hospital admission, are independently associated with functional outcome and mortality after isolated moderate-to-severe TBI.
Journal ArticleDOI
Application of Blood-Based Biomarkers in Human Mild Traumatic Brain Injury
TL;DR: A number of current experimental peripheral blood biomarkers of mTBI are highlighted to highlight their clinical application and utility, as well as comment on the issues surrounding their clinical applications and utility.