A
Alex Y. Strongin
Researcher at Discovery Institute
Publications - 177
Citations - 14746
Alex Y. Strongin is an academic researcher from Discovery Institute. The author has contributed to research in topics: Matrix metalloproteinase & Furin. The author has an hindex of 58, co-authored 176 publications receiving 13929 citations. Previous affiliations of Alex Y. Strongin include Sanford-Burnham Institute for Medical Research & Torrey Pines Institute for Molecular Studies.
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Methods related to mmp26 status as a diagnostic and prognostic tool in cancer management
TL;DR: In this paper, compositions and methods involving identifying MMP-26 in a subject with cancer were described and described. But they did not specify the methods used to identify the cancer type.
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Proteolysis-Driven Oncogenesis
TL;DR: Novel findings suggest that MMPs are directly involved in the early stages of cell transformation from normalcy to malignancy and in incipient cancer, and presents a novel concept of a proteolysis-driven oncogenesis.
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High-Throughput Multiplexed Peptide-Centric Profiling Illustrates Both Substrate Cleavage Redundancy and Specificity in the MMP Family
Muskan Kukreja,Sergey A. Shiryaev,Piotr Cieplak,Norihito Muranaka,David A. Routenberg,Andrei V. Chernov,Sonu Kumar,Albert G. Remacle,Jeffrey W. Smith,Igor A. Kozlov,Alex Y. Strongin +10 more
TL;DR: This study employed a high-throughput multiplexed peptide-centric profiling technology involving the cleavage of 18,583 peptides by 18 proteinases from the main sub-groups of the MMP family, resulting in a roadmap for the subsequent MMP structural-functional studies and efficient substrate and inhibitor design.
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Biochemical Characterization of the Cellular Glycosylphosphatidylinositol-linked Membrane Type-6 Matrix Metalloproteinase
Ilian A. Radichev,Albert G. Remacle,Sergey A. Shiryaev,Angela Purves,Sherida L. Johnson,Maurizio Pellecchia,Alex Y. Strongin +6 more
TL;DR: Because MT6-MMP has been suggested to play a role in disease, including cancer and autoimmune multiple sclerosis, the identity of its physiologically relevant cleavage targets remains to be determined.
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Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injury.
Albert G. Remacle,Swathi K. Hullugundi,Swathi K. Hullugundi,Jennifer Dolkas,Jennifer Dolkas,Mila Angert,Mila Angert,Andrei V. Chernov,Alex Y. Strongin,Veronica I. Shubayev,Veronica I. Shubayev +10 more
TL;DR: The present study offers the first evidence for the excessive, uninhibited proteolytic MMP-9 activity during late-phase painful peripheral neuropathy and suggests that the pattern of M MP-9 expression, activity, and excretion after peripheral nerve injury is universal in both sexes.