S
Sonu Kumar
Researcher at Scripps Research Institute
Publications - 48
Citations - 888
Sonu Kumar is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Raman spectroscopy & Medicine. The author has an hindex of 15, co-authored 40 publications receiving 659 citations. Previous affiliations of Sonu Kumar include International AIDS Vaccine Initiative & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen.
Colin Havenar-Daughton,Colin Havenar-Daughton,Anita Sarkar,Anita Sarkar,Daniel W. Kulp,Laura Toy,Laura Toy,Xiaozhen Hu,Xiaozhen Hu,Isaiah Deresa,Oleksandr Kalyuzhniy,Oleksandr Kalyuzhniy,Kirti Kaushik,Kirti Kaushik,Amit A. Upadhyay,Sergey Menis,Sergey Menis,Elise Landais,Elise Landais,Liwei Cao,Jolene K. Diedrich,Sonu Kumar,Sonu Kumar,Torben Schiffner,Torben Schiffner,Samantha M. Reiss,Samantha M. Reiss,Grégory Seumois,John R. Yates,James C. Paulson,Steven E. Bosinger,Ian A. Wilson,William R. Schief,Shane Crotty,Shane Crotty,Shane Crotty +35 more
TL;DR: Assessment of antigen-specific human naive B cells among hundreds of millions of B cells from multiple donors may be used as pre–phase 1 ex vivo human testing to potentially forecast B cell and Ab responses to new vaccine designs.
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Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence.
Kwinten Sliepen,Byung Woo Han,Byung Woo Han,Ilja Bontjer,Petra Mooij,Fernando Garces,Fernando Garces,Anna-Janina Behrens,Anna-Janina Behrens,Kimmo Rantalainen,Sonu Kumar,Anita Sarkar,Philip J. M. Brouwer,Yuanzi Hua,Monica Tolazzi,Edith E. Schermer,Jonathan L. Torres,Gabriel Ozorowski,Patricia van der Woude,Alba Torrents de la Peña,Mariëlle J. van Breemen,Juan Miguel Camacho-Sánchez,Judith A. Burger,Max Medina-Ramírez,Nuria González,José Alcamí,Celia C. LaBranche,Gabriella Scarlatti,Marit J. van Gils,Max Crispin,Max Crispin,David C. Montefiori,Andrew B. Ward,Gerrit Koopman,John P. Moore,Robin J. Shattock,Willy M. J. M. Bogers,Ian A. Wilson,Rogier W. Sanders,Rogier W. Sanders +39 more
TL;DR: A SOSIP trimer based on the consensus sequence of group M isolates is generated, its structure and exposure of common epitopes are determined, and immunogenicity in rabbits and non-human primates is shown.
Journal ArticleDOI
HIV-1 vaccine design through minimizing envelope metastability
Linling He,Sonu Kumar,Sonu Kumar,Joel D. Allen,Deli Huang,Xiaohe Lin,Colin J. Mann,Karen L. Saye-Francisco,Jeffrey Copps,Anita Sarkar,Anita Sarkar,Gabrielle S. Blizard,Gabriel Ozorowski,Gabriel Ozorowski,Devin Sok,Devin Sok,Max Crispin,Andrew B. Ward,Andrew B. Ward,David Nemazee,Dennis R. Burton,Ian A. Wilson,Jiang Zhu +22 more
TL;DR: For 10 strains across five clades, it is demonstrated that the gp41 ectodomain (gp41ECTO) is the main source of envelope metastability by replacing wild-type gp41ectO with BG505 gp41ECTo of the uncleaved prefusion-optimized (UFO) design.
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Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes.
Rajesh P. Ringe,Pavel Pugach,Christopher A. Cottrell,Celia C. LaBranche,Gemma E. Seabright,Thomas J. Ketas,Gabriel Ozorowski,Sonu Kumar,Anna Schorcht,Marit J. van Gils,Max Crispin,David C. Montefiori,Ian A. Wilson,Andrew B. Ward,Rogier W. Sanders,Rogier W. Sanders,Per Johan Klasse,John P. Moore +17 more
TL;DR: In HIV-1 vaccine research, native-like, soluble envelope glycoprotein SOSIP trimers are widely used for immunizing animals and there is evidence for redirection of the NAb response to a neoepitope when this site was knocked in and the N356-glycan site knocked out.
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Caspase cleavage sites in the human proteome: CaspDB, a database of predicted substrates.
TL;DR: This work developed a caspase cleavage prediction method using the recently published curated MerCASBA database of experimentally determined caspases and a Random Forest classification method that is superior to all previously developed prediction methods.