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Alex Zheleznyak
Researcher at Washington University in St. Louis
Publications - 8
Citations - 1593
Alex Zheleznyak is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Cell. The author has an hindex of 4, co-authored 5 publications receiving 1337 citations.
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Journal ArticleDOI
Role of CD47 as a marker of self on red blood cells.
Per-Arne Oldenborg,Alex Zheleznyak,Yi-Fu Fang,Carl F. Lagenaur,Hattie D. Gresham,Frederik P. Lindberg +5 more
TL;DR: It is shown that CD47 (integrin-associated protein) functions as a marker of self on murine red blood cells and may represent a potential pathway for the control of hemolytic anemia.
Journal ArticleDOI
Evaluation of Cu-64 and Ga-68 Radiolabeled Glucagon-Like Peptide-1 Receptor Agonists as PET Tracers for Pancreatic β cell Imaging
Nilantha Bandara,Alex Zheleznyak,Kaavya Cherukuri,David A. Griffith,Chris Limberakis,David A. Tess,Chen Jianqing,Rikki N. Waterhouse,Suzanne E. Lapi +8 more
TL;DR: First evidence of pancreatic uptake visualized with exendin-4 derivative in a rat animal model via in vivo dynamic PET imaging is reported, indicating it can be used as PET imaging agents specific for GLP-1R expressed on β cells.
Journal ArticleDOI
Development of 89Zr-Ontuxizumab for in vivo TEM-1/endosialin PET applications
S.S. Lange,Alex Zheleznyak,Matthew Studer,Daniel J. O'shannessy,Suzanne E. Lapi,Brian A. Van Tine +5 more
TL;DR: Reliable PET imaging of TEM-1 in sarcoma patients may allow for identification of patients that will attain the greatest benefit from anti-Tem-1 therapy, and for stratification of patients, potentially enhancing clinical outcomes seen with Ontuxizumab.
Journal ArticleDOI
Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance
Saeed Arefanian,Daniel Schäll,Stephanie Chang,Reza Ghasemi,Ryuji Higashikubo,Alex Zheleznyak,Yizhan Guo,Jinsheng Yu,Hosseinali Asgharian,Wenjun Li,Andrew E. Gelman,Daniel Kreisel,Anthony R. French,Hani S. Zaher,Beatrice Plougastel-Douglas,Leonard B. Maggi,Wayne M. Yokoyama,Sandra Beer-Hammer,Alexander S. Krupnick +18 more
TL;DR: A correlation between NK levels of the X-chromosome-located adaptor protein SLy1 and immunologic susceptibility to cancer is identified and a previously unappreciated X-linked ribosomopathy is defined that results in a specific and subtle NK cell dysfunction leading to immunologic susceptible to cancer.
Journal Article
CD47 as a potential target for molecular imaging
TL;DR: In this paper, an anti-CD47 antibody was conjugated to the Zr chelator, desferroxamine, and the resulting complex was labeled with Zr-89 at 37°C for 1 hour.