Ryuji Higashikubo

TL;DR: The hypothesis that mitochondrial O2*- and H2O2 significantly contribute to glucose deprivation-induced cytotoxicity and metabolic oxidative stress in human cancer cells is strongly supported.

TL;DR: It is demonstrated that ferrostatin-1 (Fer-1), a specific inhibitor of ferroptosis, decreases the level of pro-ferroptotic hydroperoxy-arachidonoyl-phosphatidylethanolamine, reduces cardiomyocyte cell death and blocks neutrophil recruitment following heart transplantation.

TL;DR: The hypothesis that a redox cycle within the mammalian cell cycle might provide a mechanistic link between the metabolic processes early in G(0)-G(1) and the activation of G(1)-regulatory proteins in preparation for the entry of cells into S phase is supported.

TL;DR: It is shown that hyperthermia, an effective radiosensitizer, can induce several steps associated with IR signaling in cells, and activation of ATM or other components of the IR-induced signaling pathway by heat may interfere with the normal IR- induced signaling required for chromosomal DNA double-strand break repair, thus resulting in increased cellular radiosensitivity.

TL;DR: Results show that exposure of Molt-4 cells to CDMA, FDMA, iDEN or TDMA modulated RF radiation does not induce alterations in level of DNA damage or induce apoptosis.