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Alexander Goginashvili
Researcher at University of California, San Diego
Publications - 3
Citations - 237
Alexander Goginashvili is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Stress granule & DNA repair. The author has an hindex of 2, co-authored 3 publications receiving 143 citations. Previous affiliations of Alexander Goginashvili include University of California, Berkeley & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.
Fátima Gasset-Rosa,Carlos Chillon-Marinas,Alexander Goginashvili,Ranjit Singh Atwal,Jonathan W. Artates,Ricardos Tabet,Vanessa C. Wheeler,Anne G. Bang,Don W. Cleveland,Clotilde Lagier-Tourenne +9 more
TL;DR: Overall, the findings identify polyglutamine-dependent inhibition of nucleocytoplasmic transport and alteration of nuclear integrity as a central component of Huntington's disease.
Journal ArticleDOI
Causes and consequences of micronuclei.
TL;DR: In this paper, the authors discuss how micronuclei are generated, what the consequences are, and what cellular mechanisms can be applied to protect against micronuclearation, with a focus on the effects of DNA degradation.
Posted ContentDOI
Heat shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition
Shan Lu,Shan Lu,Jiaojiao Hu,Bankhole Aladesuyi,Alexander Goginashvili,Alexander Goginashvili,Sonia Vazquez-Sanchez,Sonia Vazquez-Sanchez,Jolene K. Diedrich,Jinge Gu,Jacob A. Blum,Spencer Oung,Spencer Oung,Haiyang Yu,John Ravits,Cong Liu,John R. Yates,Don W. Cleveland,Don W. Cleveland +18 more
TL;DR: The authors showed that transient oxidative stress, proteasome inhibition, or inhibition of ATP-dependent chaperone activity provokes reversible cytoplasmic TDP-43 de-mixing and transition from liquid to gel/solid, independent of RNA binding or stress granules.