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Alexander H. Lucas
Researcher at Children's Hospital Oakland Research Institute
Publications - 46
Citations - 1764
Alexander H. Lucas is an academic researcher from Children's Hospital Oakland Research Institute. The author has contributed to research in topics: Antibody & Haemophilus influenzae. The author has an hindex of 26, co-authored 46 publications receiving 1738 citations.
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Journal ArticleDOI
Avidity as a Determinant of the Protective Efficacy of Human Antibodies to Pneumococcal Capsular Polysaccharides
TL;DR: It is concluded that avidity functions as an important determinant of anticapsular antibody protective efficacy against pneumococci.
Journal ArticleDOI
Antibody responses to Haemophilus influenzae type B vaccines in men with human immunodeficiency virus infection.
Mark C. Steinhoff,Barry S. Auerbach,Kenrad E. Nelson,David Vlahov,Rebecca L. Becker,Neil M.H. Graham,David H. Schwartz,Alexander H. Lucas,Richard E. Chaisson +8 more
TL;DR: Immunization with the PRP-CRM conjugate vaccine early in the course of HIV infection is likely to confer protection against disease caused by H. influenzae type b.
Journal ArticleDOI
Recurrent variable region gene usage and somatic mutation in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae type 23F.
Jianhui Zhou,Kathleen R. Lottenbach,Stephen J. Barenkamp,Alexander H. Lucas,Donald C. Reason +4 more
TL;DR: It is determined that, in spite of the combinatorial diversity available to the immune system, the 23F-specific response is highly restricted at the population level, with the same two L-chain-determined paratope families recurring in all individuals.
Journal Article
Functional differences in idiotypically defined IgG1 anti-polysaccharide antibodies elicited by vaccination with Haemophilus influenzae type B polysaccharide-protein conjugates.
Alexander H. Lucas,D M Granoff +1 more
TL;DR: It is demonstrated that the molecular form of the Hib PS immunogen dictates both V region usage and quality of Ab function, as well as both in vitro bactericidal activity and rat protective activity.
Journal ArticleDOI
Effect of immunity to the carrier protein on antibody responses to Haemophilus influenzae type b conjugate vaccines
TL;DR: In infants in whom diphtheria-tetanus-pertussis (DTP) vaccination is deferred because of medical contraindications, vaccination with the PRP-OMPC conjugate would appear to be preferable to HbOC because of the ability of the former to elicit antibody responses in the absence of diphTheria toxoid vaccination.