A
Alexander M. van der Bliek
Researcher at University of California, Los Angeles
Publications - 56
Citations - 12750
Alexander M. van der Bliek is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Mitochondrion & Mitochondrial fission. The author has an hindex of 34, co-authored 51 publications receiving 11102 citations. Previous affiliations of Alexander M. van der Bliek include California Institute of Technology.
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Journal ArticleDOI
Mitochondrial Fission, Fusion, and Stress
TL;DR: In their Perspective, Hoppins and Nunnari explain that the endoplasmic reticulum is an active participant in mitochondrial division and discuss how mitochondrial dynamics and cell death are linked.
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Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells
TL;DR: It is shown that mutations in the human dynamin-related protein Drp1 cause mitochondria to form perinuclear clusters that consist of highly interconnected mitochondrial tubules, which indicates that the balance between mitochondrial division and fusion is shifted toward fusion.
Journal ArticleDOI
A Human Dynamin-related Protein Controls the Distribution of Mitochondria
TL;DR: It is proposed that Drp1 is important for distributing mitochondrial tubules throughout the cell and represents a novel role for a member of the dynamin family of proteins.
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Mutations in human dynamin block an intermediate stage in coated vesicle formation
Alexander M. van der Bliek,Alexander M. van der Bliek,Thomas E. Redelmeier,Hanna Damke,Ellen J. Tisdale,Elliot M. Meyerowitz,Sandra L. Schmid +6 more
TL;DR: Results demonstrate that mutations in the GTP-binding domain of dynamin block Tfn-endocytosis in mammalian cells and suggest that a functional dynamin GTPase is required for receptor-mediated endocytotic via clathrin-coated pits.
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The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells.
TL;DR: It is concluded that Mff is a novel component of a conserved membrane fission pathway used for constitutive and induced fission of mitochondria and peroxisomes.